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J-GLOBAL ID：202002218065220580   Reference number：20A1762150

Generation of novel Il2rg-knockout mice with clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9

Clustered regularly interspaced short palindromic repeats(CRISPR)とCas9による新たなIl2rg-ノックアウトマウスの作出

Author (15)： Byambaa Suvd (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Uosaki Hideki (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Uosaki Hideki (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Hara Hiromasa (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Hara Hiromasa (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Nagao Yasumitsu (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Nagao Yasumitsu (Center for Experimental Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Abe Tomoyuki (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Abe Tomoyuki (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Shibata Hiroaki (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Shibata Hiroaki (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Nureki Osamu (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Ohmori Tsukasa (Department of Biochemistry, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Hanazono Yutaka (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Hanazono Yutaka (Center for Development of Advanced Medical Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan)
Material： Experimental Animals (Web)
Volume： 69  Issue： 2  Page： 189-198(J-STAGE)  Publication year： 2020 
JST Material Number： U2149A  ISSN： 1881-7122  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： *CRISPR-Cas9 system ,...

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Author keywords (5)： animal model ,  clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 ,  genome-editing ,  II2rg ,  X-linked severe combined immunodeficiency (X-SCID)

JST classification (4)： Congenital diseases,deformities in general.  (GD03010V) ,  Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Research methods in genetics  (EC01020N) ,  Laboratry organisms  (EA03070Y)

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Terms in the title (3)： CRISPR ,  Cas9 ,  ノックアウトマウス