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J-GLOBAL ID：202002219361769365   Reference number：20A1060208

Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization

癌由来Utx TPR変異G137VとD333GはMLL3/4複合体との相互作用を損ない,Utx細胞内局在に影響する【JST・京大機械翻訳】

Author (12)： Kato Hiroyuki (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Republic of Singapore) ,  Kato Hiroyuki (Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan) ,  Kato Hiroyuki (Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Science, Nagoya, Japan) ,  Asamitsu Kaori (Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Science, Nagoya, Japan) ,  Sun Wendi (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Republic of Singapore) ,  Kitajima Shojiro (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Republic of Singapore) ,  Kitajima Shojiro (The Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan) ,  Yoshizawa-Sugata Naoko (Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan) ,  Okamoto Takashi (Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Science, Nagoya, Japan) ,  Masai Hisao (Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan) ,  Poellinger Lorenz (Cancer Science Institute of Singapore, National University of Singapore, Singapore, Republic of Singapore) ,  Poellinger Lorenz (Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden)
Material： Oncogene
Volume： 39  Issue： 16  Page： 3322-3335  Publication year： 2020 
JST Material Number： T0406A  ISSN： 0950-9232  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: The ubiquitously tra...

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Thesaurus term： *interaction ,  amino acid ,  Cytoplasm ,  Proteins ,  Carcinogenesis ,  Leukemia ,  Agar ,  *complex (substance) ,  methyltransferase ,  deletion mutation ,  histone H3 ,  colonisation ,  *intracellular localization ,  tumor suppressor
Semi thesaurus term： 腫瘍抑制 , 【Automatic Indexing@JST】

JST classification (1)： Gene expression  (EC02040Q)

Terms in the title (7)： 癌 ,  UTX ,  TPR ,  変異 ,  複合体 ,  相互作用 ,  細胞内局在