Art

J-GLOBAL ID：202002221769282650   Reference number：20A0649767

Pharmacokinetics of Three Oximes in a Guinea Pig Model and Efficacy of Combined Oxime Therapy

モルモットモデルにおける3つのオキシムの薬物動態と併用オキシム療法の有効性【JST・京大機械翻訳】

Author (5)： Bohnert Sara (Defense Research and Development Canada - Suffield Research Centre, Casualty Management Section, PO Box 4000 Station Main, Medicine Hat, Alberta, T1A 8K6, Canada) ,  van den Berg Roland M. (TNO Defense, Security and Safety, CBRN Protection, Lange Kleiweg 137, 2288 GJ, Rijswijk, the Netherlands) ,  Mikler John (Defense Research and Development Canada - Suffield Research Centre, Casualty Management Section, PO Box 4000 Station Main, Medicine Hat, Alberta, T1A 8K6, Canada) ,  Klaassen Steven D. (TNO Defense, Security and Safety, CBRN Protection, Lange Kleiweg 137, 2288 GJ, Rijswijk, the Netherlands) ,  Joosen Marloes J.A. (TNO Defense, Security and Safety, CBRN Protection, Lange Kleiweg 137, 2288 GJ, Rijswijk, the Netherlands)
Material： Toxicology Letters  (Toxicol Lett)
Volume： 324  Page： 86-94  Publication year： 2020 
JST Material Number： E0034B  ISSN： 0378-4274  CODEN： TOLED5  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Organophosphorus nerve agents ...

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Thesaurus term： combination therapy ,  nervinum ,  seizure(disease) ,  covalent bond ,  arm(machine element) ,  nucleophilic reagent ,  anticonvulsant ,  central nervous system ,  chloride ,  peripheral nerve ,  acetylcholinesterase ,  *oxime ,  *guinea pig ,  self administration ,  cholinesterase

Author keywords (8)： Oxime ,  HI-6 ,  Pralidoxime ,  Obidoxime ,  Sarin ,  Pharmacokinetics ,  Efficacy ,  Combined therapy

JST classification (3)： Antidotes  (GZ04020B) ,  Enzyme in general  (EB09010D) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Terms in the title (7)： モルモット ,  モデル ,  オキシム ,  薬物動態 ,  併用 ,  療法 ,  有効性