Art

J-GLOBAL ID：202002221989403068   Reference number：20A2487624

Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1

低温EM構造はヒト多剤輸送体ABCB1の阻害の異なる機構を明らかにする【JST・京大機械翻訳】

Author (8)： Nosol Kamil (Institute of Molecular Biology and Biophysics, ETH Zuerich, 8093 Zuerich, Switzerland) ,  Romane Ksenija (Institute of Molecular Biology and Biophysics, ETH Zuerich, 8093 Zuerich, Switzerland) ,  Irobalieva Rossitza N. (Institute of Molecular Biology and Biophysics, ETH Zuerich, 8093 Zuerich, Switzerland) ,  Alam Amer (Institute of Molecular Biology and Biophysics, ETH Zuerich, 8093 Zuerich, Switzerland) ,  Alam Amer (The Hormel Institute, University of Minnesota, Austin, MN 55912) ,  Kowal Julia (Institute of Molecular Biology and Biophysics, ETH Zuerich, 8093 Zuerich, Switzerland) ,  Fujita Naoya (The Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31, Ariake, 135-8550 Koto-ku, Tokyo, Japan) ,  Locher Kaspar P. (Institute of Molecular Biology and Biophysics, ETH Zuerich, 8093 Zuerich, Switzerland)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 117  Issue： 42  Page： 26245-26253  Publication year： 2020 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： ABCB1 detoxifies cells by expo...

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Thesaurus term： *low temperature ,  substrate(biochemistry) ,  antitumor drug ,  antibody ,  tumor cell ,  human(primates) ,  multiplex ,  binding site ,  complex(substance) ,  inhibitor ,  peristalsis ,  monoclonal antibody ,  multiple drug resistance
Semi thesaurus term： ナノディスク ,  小分子阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： ABC transporter ,  ABCB1 ,  P-glycoprotein ,  single-particle cryoelectron microscopy ,  structure

JST classification (2)： Biological function  (EB03040U) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Terms in the title (6)： 低温 ,  EM ,  ヒト ,  輸送体 ,  ABCB1 ,  阻害