Art

J-GLOBAL ID：202002223011902107   Reference number：20A2511821

Non-Transcriptional and Translational Function of Canonical NF-κB Signaling in Activating ERK1/2 in IL-1β-Induced COX-2 Expression in Synovial Fibroblasts

滑膜線維芽細胞におけるIL-1β誘導COX-2発現のERK1/2活性化における正準NF-κBシグナリングの非転写および翻訳機能【JST・京大機械翻訳】

Author (15)： Nakano Rei (1Laboratory for Cellular Function Conversion Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan) ,  Nakano Rei (2Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan) ,  Nakano Rei (3Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan) ,  Kitanaka Taku (2Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan) ,  Kitanaka Taku (3Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan) ,  Namba Shinichi (2Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan) ,  Namba Shinichi (3Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan) ,  Kitanaka Nanako (2Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan) ,  Kitanaka Nanako (3Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan) ,  Suwabe Yoko (2Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan) ,  Konno Tadayoshi (3Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan) ,  Yamazaki Jun (4Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan) ,  Nakayama Tomohiro (2Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan) ,  Sugiya Hiroshi (2Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan) ,  Sugiya Hiroshi (3Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan)
Material： Frontiers in Immunology (Web)
Volume： 11  Page： 579266  Publication year： 2020 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The pro-inflammatory cytokine ...

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Thesaurus term： *fibroblast ,  phosphorylation ,  *synovial membrane ,  cyclooxygenase ,  Up-Regulation ,  rheumatoid arthritis ,  *interleukin 1 ,  pathogenesis ,  *NF-kappaB ,  inflammatory cytokine ,  siRNA ,  Interleukin-1beta ,  *Erk1/2 ,  Signal Transduction ,  *joint(animal)
Semi thesaurus term： cellular signal transduction ,  p65 , 【Automatic Indexing@JST】

Author keywords (5)： rheumatoid arthritis ,  interleukin 1β (IL-1β) ,  cyclooxygenase 2 (COX-2) ,  NF-κB-nuclear factor kappa B ,  ERK1/2

JST classification (2)： Basic medicine on musculoskeletal system  (GG01020B) ,  Cell physiology in general  (EF02010S)

Reference (45)：

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• GabayCLamacchiaCPalmerG. IL-1 pathways in inflammation and human diseases. Nat Rev Rheumatol (2010) 6:232-41. doi: doi: 10.1038/nrrheum.2010.4
• GabayC. IL-1 inhibitors: novel agents in the treatment of rheumatoid arthritis. Expert Opin Investig Drugs (2000) 9:113-27. doi: doi: 10.1517/13543784.9.1.113
• LawrenceT. The nuclear factor NF-κB pathway in inflammation. Cold Spring Harbor Pespect Biol (2009) 1:a001651. doi: doi: 10.1101/cshperspect.a001651

Terms in the title (11)： 滑膜線維芽細胞 ,  IL-1β ,  誘導 ,  COX-2 ,  発現 ,  ERK1 ,  活性化 ,  NF-κB ,  シグナリング ,  転写 ,  翻訳