Art

J-GLOBAL ID：202002223853871825   Reference number：20A1033824

A novel inhibitor of NF-κB-inducing kinase prevents bone loss by inhibiting osteoclastic bone resorption in ovariectomized mice

NF-κB誘導キナーゼの新規阻害剤は卵巣切除マウスにおける破骨細胞骨吸収を阻害することにより骨損失を予防する【JST・京大機械翻訳】

Author (13)： Takakura Nana (Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan) ,  Takakura Nana (Division of Endodontics and Restorative Dentistry, Department of Science of Oral Functions, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu 803-8580, Japan) ,  Matsuda Miho (Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan) ,  Khan Masud (Department of Basic Oral Health Engineering, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8549, Japan) ,  Hiura Fumitaka (Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan) ,  Aoki Kazuhiro (Department of Basic Oral Health Engineering, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8549, Japan) ,  Hirohashi Yuna (Department of Basic Oral Health Engineering, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyo-ku, Tokyo 113-8549, Japan) ,  Mori Kayo (Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan) ,  Yasuda Hisataka (Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd., 50 Kano-cho, Nagahama, Shiga 526-0804, Japan) ,  Hirata Masato (Oral Medicine Research Center, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan) ,  Kitamura Chiaki (Division of Endodontics and Restorative Dentistry, Department of Science of Oral Functions, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu 803-8580, Japan) ,  Jimi Eijiro (Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan) ,  Jimi Eijiro (Oral Health/Brain Health/Total Health Research Center, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan)
Material： Bone (New York)  (Bone (N.Y.))
Volume： 135  Page： Null  Publication year： 2020 
JST Material Number： E0177D  ISSN： 8756-3282  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Musculoskeletal diseases and d...

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Thesaurus term： gene ,  osteogenesis ,  mutation ,  side effect ,  phosphorylation ,  drug therapy ,  *bone resorption ,  *osteoclast ,  osteoporosis ,  rheumatoid arthritis ,  in vitro experiment ,  osteoblast ,  *NF-kappaB ,  RANKL
Semi thesaurus term： 破骨細胞形成 , 【Automatic Indexing@JST】

Author keywords (3)： NIK ,  Osteoclasts ,  Osteoporosis

JST classification (2)： Basic medicine on musculoskeletal system  (GG01020B) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Terms in the title (11)： NF-κB ,  誘導 ,  キナーゼ ,  阻害剤 ,  卵巣切除 ,  マウス ,  破骨細胞 ,  骨吸収 ,  阻害 ,  骨損失 ,  予防