Art

J-GLOBAL ID：202002224429299327   Reference number：20A1417450

Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells

スタウロスポリンとベネトクラックスはMEF2D融合蛋白質のカスパーゼ依存性蛋白質分解を誘導し,MEF2D融合(+)ALL細胞におけるアポトーシスを誘導する【JST・京大機械翻訳】

Author (11)： Tange Naoyuki (Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Hayakawa Fumihiko (Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Hayakawa Fumihiko (Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Yasuda Takahiko (Clinical Research Center, Nagoya Medical Center, National Hospital Organization, Nagoya, Japan) ,  Odaira Koya (Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Yamamoto Hideyuki (Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Hirano Daiki (Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Sakai Toshiyasu (Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Terakura Seitaro (Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Tsuzuki Shinobu (Department of Biochemistry, Aichi Medical University, School of Medicine, Japan) ,  Kiyoi Hitoshi (Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan)
Material： Biomedicine & Pharmacotherapy  (Biomedicine and Pharmacotherapy)
Volume： 128  Page： Null  Publication year： 2020 
JST Material Number： A0845C  ISSN： 0753-3322  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： MEF2D-fusion (M-fusion) genes ...

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Thesaurus term： gene ,  luciferase ,  inhibition of multiplication ,  *proteolysis ,  myeloid cell ,  *fusion protein ,  *Apoptosis ,  *caspase ,  Cell Line ,  luciferase assay ,  Caspase Inhibitor ,  Proteasome Inhibitor ,  293T cell ,  protein expression ,  ether ,  lactam ,  oxygen heterocyclic compound ,  bridged compound ,  polynuclear aromatic compound ,  secondary amine

Author keywords (6)： MEF2D ,  High throughput screening ,  Acute lymphoblastic leukemia ,  Staurosporine ,  Drug repositioning ,  Drug discovery

JST classification (5)： Blood cell tumors(=neoplasms)  (GK04000M) ,  Basic neurology  (GN01020W) ,  Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q)

Substance index (1)： Staurosporine

Terms in the title (9)： スタウロスポリン ,  ベネトクラックス ,  融合蛋白質 ,  カスパーゼ ,  依存性 ,  蛋白質分解 ,  誘導 ,  融合 ,  アポトーシス