Art

J-GLOBAL ID：202002225638633372   Reference number：20A0200340

The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation

セラミド類似体N-(1-ヒドロキシ-3-モルホリノ-1-フェニルプロパン-2-イル)デカンアミドは大きな脂質滴蓄積を誘導し,脂質滴分解に対するLAMP-2欠乏の影響を明らかにする【JST・京大機械翻訳】

Author (8)： Kato Yuji (Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan) ,  Arakawa Satoko (Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan) ,  Terasawa Kazue (Department of Biochemistry, Graduate School of Medical and Dental Sciences, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan) ,  Inokuchi Jin-ichi (Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan) ,  Iwata Takanori (Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan) ,  Shimizu Shigeomi (Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan) ,  Watabe Tetsuro (Department of Biochemistry, Graduate School of Medical and Dental Sciences, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan) ,  Hara-Yokoyama Miki (Department of Biochemistry, Graduate School of Medical and Dental Sciences, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 30  Issue： 3  Page： Null  Publication year： 2020 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Excess accumulation of intrace...

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Thesaurus term： dissimilation ,  lysosome ,  *lipid ,  Membrane Proteins ,  *ceramide ,  Autophagy ,  Lipolysis ,  Hydrolysis ,  Endosomes ,  electron microscope ,  lipase ,  L cell ,  Endoplasmic Reticulum ,  *LAMP ,  Organelles ,  membrane and film ,  biomembrane ,  Endomembrane system ,  Vesicles
Semi thesaurus term： cell organelle , 【Automatic Indexing@JST】

Author keywords (6)： Lipid droplet ,  Lipophagy ,  LAMP-2 ,  PDMP ,  Multilamellar bodies ,  Autolysosome

JST classification (4)： Nucleic acids in general  (EB04010U) ,  Synthesis of drugs  (GV01030F) ,  Plant biochemistry  (EH01050J) ,  Imidazoles  (CF07083X)

Terms in the title (10)： セラミド ,  類似体 ,  1-フェニルプロパン ,  デカンアミド ,  脂質滴 ,  蓄積 ,  誘導 ,  分解 ,  LAMP ,  欠乏