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J-GLOBAL ID：202002226307145122   Reference number：20A0482365

Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor

細胞外ADPはP2Y12受容体を介してミクログリアインフラマソームとNF-κB活性化を増強する【JST・京大機械翻訳】

Author (11)： Suzuki Tomonori (Developmental Neuroimmunology Project, Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan) ,  Suzuki Tomonori (Department of Pediatrics and Developmental Biology, Bio-Environmental Response Division, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Kohyama Kuniko (Developmental Neuroimmunology Project, Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan) ,  Moriyama Kengo (Developmental Neuroimmunology Project, Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan) ,  Ozaki Mariko (Developmental Neuroimmunology Project, Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan) ,  Hasegawa Setsuko (Developmental Neuroimmunology Project, Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan) ,  Ueno Taro (Learning and Memory Project, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan) ,  Saitoe Minoru (Learning and Memory Project, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan) ,  Morio Tomohiro (Department of Pediatrics and Developmental Biology, Bio-Environmental Response Division, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Hayashi Masaharu (Developmental Neuroimmunology Project, Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan) ,  Sakuma Hiroshi (Developmental Neuroimmunology Project, Department of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan)
Material： European Journal of Immunology  (Eur J Immunol)
Volume： 50  Issue： 2  Page： 205-219  Publication year： 2020 
JST Material Number： H0462B  ISSN： 0014-2980  CODEN： EJIMAF  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： The NLRP3 inflammasome is a mo...

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Thesaurus term： *microglia ,  pathogen ,  purine receptor ,  nervous system disease ,  excitometabolism ,  inflammation ,  siRNA ,  mRNA ,  *NF-kappaB ,  interleukin 1 ,  in vitro experiment ,  interleukin 6
Semi thesaurus term： インターロイキン1β ,  炎症反応 ,  *インフラマソーム , 【Automatic Indexing@JST】

Author keywords (4)： P2Y12 receptor ,  IL-1β ,  NLRP3 inflammasome ,  NF-κB

JST classification (1)： Immunological reaction in general  (ED03010T)

Terms in the title (5)： ADP ,  P2Y12受容体 ,  NF-κB ,  活性化 ,  増強