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J-GLOBAL ID：202002227156191662   Reference number：20A1203344

Modification of nitric oxide donors onto a monoclonal antibody boosts accumulation in solid tumors

モノクローナル抗体への一酸化窒素ドナーの修飾は固形腫瘍における蓄積を促進する【JST・京大機械翻訳】

Author (15)： Yoshikawa Takuma (Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka, Japan) ,  Phan Khanh Quoc (Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan) ,  Tagawa Hiroshi (Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan) ,  Sasaki Koichi (Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka, Japan) ,  Feng Haitao (Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka, Japan) ,  Kishimura Akihiro (Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka, Japan) ,  Kishimura Akihiro (Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan) ,  Kishimura Akihiro (International Research Center for Molecular Systems, Kyushu University, Fukuoka, Japan) ,  Mori Takeshi (Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka, Japan) ,  Mori Takeshi (Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan) ,  Katayama Yoshiki (Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka, Japan) ,  Katayama Yoshiki (Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan) ,  Katayama Yoshiki (International Research Center for Molecular Systems, Kyushu University, Fukuoka, Japan) ,  Katayama Yoshiki (Center for Advanced Medical Innovation, Kyushu University, Fukuoka, Japan) ,  Katayama Yoshiki (Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan, Taiwan)
Material： International Journal of Pharmaceutics  (Int J Pharm)
Volume： 583  Page： Null  Publication year： 2020 
JST Material Number： A0285B  ISSN： 0378-5173  CODEN： IJPHD  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Although monoclonal antibodies...

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Thesaurus term： *donor ,  serum albumin ,  antigen ,  *antibody ,  protein ,  *nitrogen monoxide ,  cytotoxicity ,  effectiveness ,  *monoclonal antibody ,  *solid tumor
Semi thesaurus term： S-ニトロソチオール ,  結合親和性 ,  透過性 ,  癌治療 ,  腫瘍集積性 , 【Automatic Indexing@JST】

Author keywords (4)： Monoclonal antibody ,  Nitric oxide ,  S-nitrosothiol ,  EPR effect

JST classification (3)： Biochemistry of antigens,antibodies,complements  (ED04020L) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D) ,  Analysis of drugs  (GV01040Q)

Terms in the title (6)： モノクローナル抗体 ,  一酸化窒素ドナー ,  修飾 ,  固形腫瘍 ,  蓄積 ,  促進