Art

J-GLOBAL ID：202002228301864417   Reference number：20A0653818

Disrupted hepatic pentose phosphate pathway directly participates in and indirectly promotes CYP3A reduction: A new strategy for CYP3A-mediated drug hepatotoxicity

破壊された肝ペントースりん酸経路は直接的にCYP3A減少を促進する:CYP3A仲介性薬物肝毒性に対する新しい戦略【JST・京大機械翻訳】

Author (9)： Liu Jiali (Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China) ,  Jin Xiaoliang (Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China) ,  Zhou Fang (Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China) ,  Chen Hongzhu (Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China) ,  Wang Wenjie (Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China) ,  Liu Yan (Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China) ,  Wang Guangji (Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China) ,  Hao Kun (Department of Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu, China) ,  Zhang Jingwei (Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China)
Material： British Journal of Pharmacology  (Br J Pharmacol)
Volume： 177  Issue： 7  Page： 1538-1555  Publication year： 2020 
JST Material Number： B0334A  ISSN： 0007-1188  CODEN： BJPCB  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： BACKGROUND AND PURPOSE: Hepati...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=20A0653818&from=J-GLOBAL&jstjournalNo=B0334A") }}

Thesaurus term： nude mouse ,  tumor ,  p53 protein ,  gene silencing ,  quantitative polymerase chain reaction ,  HepG2 cell ,  *hepatic toxicity ,  inflammation ,  glucosephosphate dehydrogenase ,  GC-MS analysis ,  Western blotting ,  cytochrome P450 ,  interleukin 6 ,  *pentose phosphate cycle ,  liver disease

JST classification (3)： Toxicity of plant derived substances  (GZ03010J) ,  Toxicity of organic compounds  (GZ02030Y) ,  Liver  (EJ06060J)

Terms in the title (8)： 破壊 ,  ペントースりん酸経路 ,  CYP3A ,  促進 ,  仲介 ,  薬物 ,  肝毒性 ,  戦略