Art

J-GLOBAL ID：202002228815201946   Reference number：20A0665025

Loss of the Periplasmic Chaperone Skp and Mutations in the Efflux Pump AcrAB-TolC Play a Role in Acquired Resistance to Antimicrobial Peptides in Salmonella typhimurium

排出ポンプAcrAB-TolCにおけるペリプラズムシャペロンSkpの消失と変異はSalmonella typhimuriumにおける抗菌ペプチドに対する獲得耐性において役割を果たす【JST・京大機械翻訳】

Author (8)： Kapach Gal (Departmant of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel) ,  Nuri Reut (Departmant of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel) ,  Schmidt Christiane (Project Group 5, Robert Koch Institute, Wernigerode, Germany) ,  Danin Adi (Departmant of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel) ,  Ferrera Shir (Departmant of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel) ,  Savidor Alon (de Botton Institute for Protein Profiling, The Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel) ,  Gerlach Roman G. (Project Group 5, Robert Koch Institute, Wernigerode, Germany) ,  Shai Yechiel (Departmant of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel)
Material： Frontiers in Microbiology (Web)
Volume： 11  Page： 189  Publication year： 2020 
JST Material Number： U7080A  ISSN： 1664-302X  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Bacterial resistance to antibi...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=20A0665025&from=J-GLOBAL&jstjournalNo=U7080A") }}

Thesaurus term： multiple drug resistance ,  binding site ,  *Periplasm ,  antibiotics ,  Gram-Negative Bacteria ,  *chaperone protein ,  biosynthesis ,  peptide bond hydrolase ,  *Salmonella enterica subsp. enterica serovar Typhimurium ,  natural immunity ,  substrate (biochemistry) ,  Bacteria ,  Mutation ,  proteolysis ,  outermembrane protein ,  *Cellular Structures ,  antibacterial drug ,  antimicrobial drug ,  drug ,  *microorganism ,  *Salmonella

Author keywords (7)： antimicrobial peptide (AMPs) ,  bacterial resistance ,  AcrAB-TolC ,  ramR ,  Skp ,  periplasm ,  efflux pump

JST classification (1)： Basic research of antibacterial drugs  (GW17020S)

Reference (74)：

• Ababou A., Koronakis V. (2016). Structures of gate loop variants of the AcrB drug efflux pump bound by erythromycin substrate. PLoS One 11:e0159154. doi: 10.1371/journal.pone.0159154
• Abouzeed Y. M., Baucheron S., Cloeckaert A. (2008). ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar typhimurium. Antimicrob. Agents Chemother. 52 2428-2434. doi: 10.1128/AAC.00084-08
• Adhya S., Ryu S., Garges S. (1995). Role of allosteric changes in cyclic AMP receptor protein function. Subcell. Biochem. 24 303-321. doi: 10.1007/978-1-4899-1727-0_10
• Bishop R. E., Gibbons H. S., Guina T., Trent M. S., Miller S. I., Raetz C. R. (2000). Transfer of palmitate from phospholipids to lipid A in outer membranes of Gram-negative bacteria. EMBO J. 19 5071-5080. doi: 10.1093/emboj/19.19.5071
• Blecher-Gonen R., Barnett-Itzhaki Z., Jaitin D., Amann-Zalcenstein D., Lara-Astiaso D., Amit I. (2013). High-throughput chromatin immunoprecipitation for genome-wide mapping of in vivo protein-DNA interactions and epigenomic states. Nat. Protoc. 8 539-554. doi: 10.1038/nprot.2013.023

Terms in the title (9)： 排出ポンプ ,  AcrAB ,  TolC ,  変異 ,  Salmonella ,  抗菌ペプチド ,  獲得 ,  耐性 ,  役割