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J-GLOBAL ID：202002229094640051   Reference number：20A1175642

Na⁺-mimicking ligands stabilize the inactive state of leukotriene B₄ receptor BLT1

Na+模倣リガンドはロイコトリエンB_4受容体BLT1の不活性状態を安定化する【JST・京大機械翻訳】

Author (17)： Hori Tetsuya (RIKEN Structural Biology Laboratory, Tsurumi-ku, Yokohama, Kanagawa, Japan) ,  Hori Tetsuya (RIKEN SPring-8 Center, Sayo, Hyogo, Japan) ,  Okuno Toshiaki (Department of Biochemistry, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan) ,  Hirata Kunio (RIKEN SPring-8 Center, Sayo, Hyogo, Japan) ,  Hirata Kunio (Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology (PRESTO), Kawaguchi, Saitama, Japan) ,  Yamashita Keitaro (RIKEN SPring-8 Center, Sayo, Hyogo, Japan) ,  Kawano Yoshiaki (RIKEN SPring-8 Center, Sayo, Hyogo, Japan) ,  Yamamoto Masaki (RIKEN SPring-8 Center, Sayo, Hyogo, Japan) ,  Hato Masakatsu (Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, Tsurumi-ku, Yokohama, Japan) ,  Nakamura Motonao (Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Nakamura Motonao (Department of Life Science, Faculty of Science, Okayama University of Science, Kita-ku, Okayama, Japan) ,  Shimizu Takao (Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan) ,  Shimizu Takao (Department of Lipid Signaling, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan) ,  Yokomizo Takehiko (Department of Biochemistry, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan) ,  Miyano Masashi (RIKEN SPring-8 Center, Sayo, Hyogo, Japan) ,  Miyano Masashi (Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Chuo-ku, Sagamihara, Kanagawa, Japan) ,  Yokoyama Shigeyuki (RIKEN Structural Biology Laboratory, Tsurumi-ku, Yokohama, Kanagawa, Japan)
Material： Nature Chemical Biology  (Nat Chem Biol)
Volume： 14  Issue： 3  Page： 262-269  Publication year： 2018 
JST Material Number： W2213A  ISSN： 1552-4450  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： A structure of leukotriene B<s...

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Thesaurus term： crystal structure ,  interaction ,  steric conformation ,  *receptor ,  chemical substance ,  G protein-coupled receptor ,  *Ligands ,  ligand binding ,  transmembrane domain ,  sodium ion ,  water cluster ,  transmembrane helix ,  aromatic carboxylic acid
Semi thesaurus term： インバースアゴニスト ,  残基 , 【Automatic Indexing@JST】

JST classification (1)： Receptors on cell membrane  (EF04030C)

Substance index (1)： Benzamidine

Terms in the title (6)： 模倣 ,  リガンド ,  受容体 ,  BLT1 ,  不活性状態 ,  安定化