Art

J-GLOBAL ID：202002229596363928   Reference number：20A1123645

Evaluation of the Role of P-glycoprotein (P-gp)-Mediated Efflux in the Intestinal Absorption of Common Substrates with Elacridar, a P-gp Inhibitor, in Rats

ラットにおけるP-gp阻害剤,エラクリダールによる共通基質の腸管吸収におけるP糖蛋白質(P-gp)媒介流出の役割の評価【JST・京大機械翻訳】

Author (4)： Suzuki Kei (Exploratory Research Section III, Exploratory Research Laboratories, Drug Research Department, TOA EIYO LTD., Fukushima-shi, Fukushima, Japan) ,  Taniyama Kazuhiro (Exploratory Research Section III, Exploratory Research Laboratories, Drug Research Department, TOA EIYO LTD., Fukushima-shi, Fukushima, Japan) ,  Aoyama Takao (Faculty of Pharmaceutical Science, Tokyo University of Science, Noda, Chiba, Japan) ,  Watanabe Yoshiaki (Exploratory Research Section III, Exploratory Research Laboratories, Drug Research Department, TOA EIYO LTD., Fukushima-shi, Fukushima, Japan)
Material： European Journal of Drug Metabolism and Pharmacokinetics
Volume： 45  Issue： 3  Page： 385-392  Publication year： 2020 
JST Material Number： H0633A  ISSN： 0378-7966  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: Background and Obje...

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Thesaurus term： absorption coefficient ,  probe ,  *substrate(biochemistry) ,  plasma concentration ,  *rat ,  cytochrome P450 ,  *P glycoprotein ,  fatty acid ,  lactam ,  sulfur heterocyclic compound ,  phenol ether ,  polynuclear aromatic compound ,  carboxylate(ester) ,  tertiary amine ,  ether ,  ketone ,  macrocyclic compound ,  nitrogen heterocyclic compound ,  oxygen heterocyclic compound ,  bridged compound ,  allyl compound ,  alicyclic alcohol ,  nitrile ,  alicyclic compound ,  enol ether ,  carboxamide ,  enone ,  side chain amine alkaloid
Semi thesaurus term： *腸管吸収 ,  輸送体 ,  CYP3A , 【Automatic Indexing@JST】

JST classification (1)： Basic biopharmacy  (GY01021U)

Substance index (5)： Diltiazem ,  Tacrolimus ,  Verapamil ,  Fexofenadine ,  Colchicine

Terms in the title (10)： ラット ,  GP ,  阻害剤 ,  エラクリダール ,  基質 ,  腸管吸収 ,  P糖蛋白質 ,  流出 ,  役割 ,  評価