Art

J-GLOBAL ID：202002230489786403   Reference number：20A0503103

Next-Generation Sequencing Panel Analysis of Clinically Relevant Mutations in Circulating Cell-Free DNA from Patients with Gestational Trophoblastic Neoplasia: A Pilot Study

妊娠性栄養芽細胞性腫瘍患者由来の循環無細胞DNAにおける臨床的に関連した変異の次世代シークエンシングパネル分析:パイロット研究【JST・京大機械翻訳】

Author (13)： Luo Lingxiao ( Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China) ,  Luo Lingxiao ( Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai 200011, China) ,  Lin Ling ( Institutes of Biomedical Sciences of Shanghai Medical School, Fudan University, Shanghai 200032, China) ,  Zhang Xiaoyan ( Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China) ,  Zhang Xiaoyan ( Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai 200011, China) ,  Cai Qingqing ( Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China) ,  Cai Qingqing ( Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai 200011, China) ,  Zhao Hongbo ( Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China) ,  Zhao Hongbo ( Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai 200011, China) ,  Xu Congjian ( Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China) ,  Xu Congjian ( Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai 200011, China) ,  Cong Qing ( Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China) ,  Cong Qing ( Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai 200011, China)
Material： BioMed Research International (Web)  (BioMed Res Int (Web))
Volume： 2020  Page： Null  Publication year： 2020 
JST Material Number： U7008A  ISSN： 2314-6133  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Gestational trophoblastic neop...

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Thesaurus term： immersional wetting ,  carcinogenesis ,  tumorigenesis ,  drug therapy ,  gene ,  human(primates) ,  up-regulation ,  molecular target therapy ,  MAP kinase kinase ,  *pregnancy ,  placenta ,  *tumor ,  mutation ,  mRNA ,  *trophoblast

JST classification (3)： Molecular genetics in general  (EC02010J) ,  Diagnosis of tumors(=neoplasms)  (GE03020J) ,  Eye diseases  (GP03000U)

Reference (28)：

• M. J. Seckl, N. J. Sebire, R. S. Berkowitz, "Gestational trophoblastic disease," The Lancet, vol. 376, no. 9742, pp. 717-729, 2010.
• A. Santaballa, Y. García, A. Herrero et al., "SEOM clinical guidelines in gestational trophoblastic disease (2017)," Clinical and Translational Oncology, vol. 20, no. 1, pp. 38-46, 2018.
• J. R. Lurain, "Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole," American Journal of Obstetrics and Gynecology, vol. 203, no. 6, pp. 531-539, 2010.
• J. T. Soper, D. G. Mutch, J. C. Schink, A. C. O. Gynecologi, "Diagnosis and treatment of gestational trophoblastic disease: ACOG practice bulletin no. 53," Gynecologic Oncology, vol. 93, no. 3, pp. 575-585, 2004.
• H. Y. S. Ngan, M. J. Seckl, R. S. Berkowitz et al., "Update on the diagnosis and management of gestational trophoblastic disease," International Journal of Gynecology & Obstetrics, vol. 143, pp. 79-85, 2018.

Terms in the title (12)： 妊娠 ,  栄養芽細胞 ,  腫瘍 ,  患者 ,  循環 ,  無細胞DNA ,  臨床 ,  変異 ,  次世代シークエンシング ,  分析 ,  パイロット ,  研究