Art

J-GLOBAL ID：202002231227501776   Reference number：20A0553590

Numerical analysis of apparent decitabine uptake in HCT116 cells: Incorporation of a bidirectional first-order kinetic parameter for ENT1 transport and Michaelis-Menten parameters for subsequent phosphorylation

HCT116細胞における見かけのデシタビン取込の数値解析:ENT1輸送の双方向一次速度論的パラメータとその後のリン酸化のためのMichaelis-Mentenパラメータの取込

Author (6)： Ueda Kumiko (Laboratory of Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan) ,  Nakamura Touko (Laboratory of Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan) ,  Tanaka Shota (Laboratory of Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan) ,  Hosokawa Mika (Laboratory of Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan) ,  Iwakawa Seigo (Laboratory of Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan) ,  Ogawara Ken-ichi (Laboratory of Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan)
Material： Drug Metabolism and Pharmacokinetics (Web)  (Drug Metab Pharmacokinet (Web))
Volume： 35  Issue： 1  Page： 124-130  Publication year： 2020 
JST Material Number： U0705A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： tumor cell ,...
Semi thesaurus term： *DNA methylation inhibitor ,...

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Author keywords (6)： Decitabine ,  Equilibrative nucleoside transporter 1 ,  Deoxycytidine kinase ,  Facilitated diffusion ,  Compartment model ,  Michaelis-Menten

JST classification (2)： Basic biopharmacy  (GY01021U) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (5)： Irinotecan ,  Etoposide ,  Gemcitabine ,  Cytarabine ,  5-Aza-2'-deoxycytidine

Terms in the title (10)： HCT116細胞 ,  デシタビン ,  取込 ,  数値解析 ,  ENT1 ,  輸送 ,  双方向 ,  速度論 ,  パラメータ ,  リン酸化