Art

J-GLOBAL ID：202002231558870420   Reference number：20A0663065

Targeted Mass Spectrometry Suggests Beta-Synuclein as Synaptic Blood Marker in Alzheimer’s Disease

標的質量分析はAlzheimer病におけるシナプス血液マーカーとしてベータ-シヌクレインを示唆する【JST・京大機械翻訳】

Author (14)： Oeckl Patrick (Department of Neurology, Ulm University Hospital, Germany) ,  Halbgebauer Steffen (Department of Neurology, Ulm University Hospital, Germany) ,  Anderl-Straub Sarah (Department of Neurology, Ulm University Hospital, Germany) ,  von Arnim Christine A. F. (Department of Neurology, Ulm University Hospital, Germany) ,  Diehl-Schmid Janine (Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, Germany) ,  Froelich Lutz (Central Institute of Mental Health Mannheim, Germany) ,  Grimmer Timo (Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, Germany) ,  Hausner Lucrezia (Central Institute of Mental Health Mannheim, Germany) ,  Denk Johannes (Department of Psychiatry, University Hospital Hamburg, Germany) ,  Jahn Holger (Department of Psychiatry, University Hospital Hamburg, Germany) ,  Steinacker Petra (Department of Neurology, Ulm University Hospital, Germany) ,  Weishaupt Jochen H. (Department of Neurology, Ulm University Hospital, Germany) ,  Ludolph Albert C. (Department of Neurology, Ulm University Hospital, Germany) ,  Otto Markus (Department of Neurology, Ulm University Hospital, Germany)
Material： Journal of Proteome Research  (J Proteome Res)
Volume： 19  Issue： 3  Page： 1310-1318  Publication year： 2020 
JST Material Number： A1632A  ISSN： 1535-3893  CODEN： JPROBS  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Synaptic degeneration is a maj...

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Thesaurus term： *synapse ,  dementia ,  *Alzheimer disease ,  differential diagnosis ,  cerebrospinal fluid ,  population(statistics) ,  *mass spectrometry ,  hematologic disease ,  protein ,  amyotrophic lateral sclerosis ,  biomarker ,  follow-up study ,  Parkinson's disease ,  clinical trial
Semi thesaurus term： 神経変性疾患 , 【Automatic Indexing@JST】

Author keywords (8)： Alzheimer’s disease ,  beta-synuclein ,  Creutzfeldt-Jakob disease ,  mass spectrometry ,  synaptic blood biomarker ,  MRM ,  cerebrospinal fluid ,  dementia

JST classification (2)： Neurologic diagnosis  (GN02000H) ,  Nervous system diseases  (GN03000O)

Terms in the title (7)： 標的 ,  質量分析 ,  Alzheimer病 ,  シナプス ,  血液 ,  マーカー ,  ベータ-シヌクレイン