Art

J-GLOBAL ID：202002233774896368   Reference number：20A0666605

Intensive first-line FIr-C/FOx-C association of triplet chemotherapy plus cetuximab in RAS wild-type metastatic colorectal cancer patients: preliminary phase II data and prediction of individual limiting toxicity syndromes by pharmacogenomic biomarkers

Ras野生型転移性結腸直腸癌患者における三重項化学療法+セツキシマブの集中的ファーストラインFIR-C/FOX-C関連: 予備的第II相データおよび薬理遺伝学的バイオマーカーによる個々の制限毒性症候群の予測【JST・京大機械翻訳】

Author (10)： Bruera Gemma (Oncology Territorial Care, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, University of L’Aquila, L’Aquila, Italy Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy) ,  Massacese Silvia (Pharmacy Unit, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, L’Aquila, Italy) ,  Pepe Francesco (Department of Public Health, University Federico II, Napoli, Italy) ,  Malapelle Umberto (Department of Public Health, University Federico II, Napoli, Italy) ,  Dal Mas Antonella (Pathology, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, L’Aquila, Italy) ,  Ciacco Eugenio (Pharmacy Unit, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, L’Aquila, Italy) ,  Calvisi Giuseppe (Pathology, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, L’Aquila, Italy) ,  Troncone Giancarlo (Department of Public Health, University Federico II, Napoli, Italy) ,  Simmaco Maurizio (Advanced Molecular Diagnostics, S. Andrea Hospital, Rome, Italy) ,  Ricevuto Enrico (U.O.S.D. Oncology Territorial Care, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Via Vetoio, L’Aquila 67100, Italy)
Material： Therapeutic Advances in Medical Oncology
Volume： 11  Page： 1758835919846421  Publication year： 2019 
JST Material Number： W5408A  ISSN： 1758-8340  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Background: Intensive triplet ...

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Thesaurus term： chi-square test ,  *wild type ,  transaminase ,  single nucleotide polymorphism ,  diarrhea ,  effectiveness ,  asthma ,  *pharmacology ,  phase 2 study ,  *drug therapy ,  *Ras protein ,  *biomarker ,  follow-up study
Semi thesaurus term： オキサリプラチン ,  ベバシズマブ , 【Automatic Indexing@JST】

Author keywords (5)： FIr-C/FOx-C triplet chemotherapy plus cetuximab ,  first line ,  metastatic colorectal cancer ,  phase II study ,  RAS wildtype

JST classification (2)： Tumors(=neoplasms)of digestive system  (GH04000D) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Terms in the title (14)： Ras ,  野生型 ,  転移性結腸直腸癌 ,  患者 ,  三重項 ,  化学療法 ,  セツキシマブ ,  第II相 ,  薬理遺伝学 ,  バイオマーカー ,  制限 ,  毒性 ,  症候群 ,  予測