Art

J-GLOBAL ID：202002233903372544   Reference number：20A1861230

Discovery and SAR of Natural-Product-Inspired RXR Agonists with Heterodimer Selectivity to PPARδ-RXR

PPARδ-RXRに対するヘテロ二量体選択性を有する天然物にヒントを得たRXRアゴニストの発見とSAR【JST・京大機械翻訳】

Author (11)： Nakashima Ken-ichi (Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, Japan) ,  Yamaguchi Eiji (Laboratory of Pharmaceutical Synthetic Chemistry, Gifu Pharmaceutical University) ,  Noritake Chihaya (Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, Japan) ,  Mitsugi Yukari (Laboratory of Pharmaceutical Synthetic Chemistry, Gifu Pharmaceutical University) ,  Goto Mayuki (Laboratory of Pharmaceutical Synthetic Chemistry, Gifu Pharmaceutical University) ,  Hirai Takao (Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, Japan) ,  Abe Naohito (Laboratory of Pharmacognosy, Gifu Pharmaceutical University) ,  Sakai Eiji (Laboratory of Herbal Garden, Gifu Pharmaceutical University) ,  Oyama Masayoshi (Laboratory of Pharmacognosy, Gifu Pharmaceutical University) ,  Itoh Akichika (Laboratory of Pharmaceutical Synthetic Chemistry, Gifu Pharmaceutical University) ,  Inoue Makoto (Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, Japan)
Material： ACS Chemical Biology
Volume： 15  Issue： 6  Page： 1526-1534  Publication year： 2020 
JST Material Number： W5037A  ISSN： 1554-8937  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： A known natural product, magna...

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Thesaurus term： optimization ,  luciferase ,  affinity ,  Magnolia ,  *retinoid X receptor ,  PPAR gamma ,  PPAR alpha ,  *PPAR delta ,  Retinoid X Receptor alpha ,  *hetero dimer ,  ligand binding domain ,  docking simulation ,  reporter assay ,  modification ,  eudicotyledons
Semi thesaurus term： *アゴニスト ,  アンタゴニスト , 【Automatic Indexing@JST】

JST classification (2)： Vitamin A  (EB07020A) ,  Receptors on cell membrane  (EF04030C)

Terms in the title (9)： PPARδ ,  RXR ,  ヘテロ二量体 ,  選択性 ,  天然物 ,  ヒント ,  アゴニスト ,  発見 ,  SAR