Art

J-GLOBAL ID：202002234732718440   Reference number：20A1781339

Antidepressant effect of BE360, a new selective estrogen receptor modulator, activated via CREB/BDNF, Bcl-2 signaling pathways in ovariectomized mice

卵巣切除マウスにおけるCREB/BDNF,Bcl-2シグナル伝達経路を介して活性化される新しい選択的エストロゲン受容体モジュレーターBE360の抗欝作用【JST・京大機械翻訳】

Author (8)： Sakuma Wakana (Department of Pharmacology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan) ,  Nakagawasai Osamu (Department of Pharmacology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan) ,  Nemoto Wataru (Department of Pharmacology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan) ,  Odaira Takayo (Department of Pharmacology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan) ,  Ogawa Takumi (Laboratory of Organic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan) ,  Ohta Kiminori (Laboratory of Organic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan) ,  Endo Yasuyuki (Laboratory of Organic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan) ,  Tan-No Koichi (Department of Pharmacology, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan)
Material： Behavioural Brain Research  (Behav Brain Res)
Volume： 393  Page： Null  Publication year： 2020 
JST Material Number： A1150A  ISSN： 0166-4328  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： We have previously reported th...

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Thesaurus term： *antidepressant action ,  subcutaneous administration ,  phosphorylation ,  Eumetopias jubata ,  reproductive cell ,  depression (disease) ,  dentate gyrus ,  *Ovariectomy ,  immunohistochemistry ,  Dementia ,  forced swim test ,  *BCL-2 ,  Neurogenesis ,  chronic stress ,  Hippocampus
Semi thesaurus term： *BDNF , 【Automatic Indexing@JST】

Author keywords (6)： Depression ,  Menopause ,  Carborane compound ,  Ovariectomy ,  Neurogenesis ,  Selective estrogen receptor modulator

JST classification (2)： Basic research of psychotropic drugs  (GW03100Y) ,  Central nervous system  (EJ12030F)

Terms in the title (9)： 卵巣切除 ,  マウス ,  CREB ,  BDNF ,  BCL-2 ,  シグナル伝達経路 ,  活性化 ,  選択的エストロゲン受容体モジュレーター ,  抗欝作用