Art

J-GLOBAL ID：202002235014460899   Reference number：20A0477205

Up-regulation of DNMT3b contributes to HOTAIRM1 silencing via DNA hypermethylation in cells transformed by long-term exposure to hydroquinone and workers exposed to benzene

DNMT3Bのアップレギュレーションは,ベンゼンに曝露されたヒドロキノンおよび労働者への長期曝露により形質転換された細胞におけるDNA過メチル化を介してHotairm1サイレンシングに寄与する【JST・京大機械翻訳】

Author (12)： Zhang Haiqiao (Department of Environmental and Occupational Health, School of Public Health, Guangdong Medical University, Dongguan, 523808, PR China) ,  Zhang Haiqiao (Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, PR China) ,  Yuan Qian (Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, PR China) ,  Pan Zhijie (Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, PR China) ,  Ling Xiaoxuan (Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, PR China) ,  Tan Qiang (Foshan Institute of Occupational Disease Prevention and Control, Foshan, Guangdong, 528000, PR China) ,  Wu Minhua (Department of Histology and Embryology, Guangdong Medical University, Zhanjiang, PR China) ,  Zheng Dongyan (Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, PR China) ,  Xie Peien (Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, PR China) ,  Xie Daxiao (Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, PR China) ,  Liu Linhua (Department of Environmental and Occupational Health, School of Public Health, Guangdong Medical University, Dongguan, 523808, PR China) ,  Liu Linhua (Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, PR China)
Material： Toxicology Letters  (Toxicol Lett)
Volume： 322  Page： 12-19  Publication year： 2020 
JST Material Number： E0034B  ISSN： 0378-4274  CODEN： TOLED5  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Benzene exposure is a risk fac...

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Thesaurus term： *worker ,  *up-regulation ,  *gene silencing ,  metabolite ,  antisense RNA ,  methyltransferase ,  promoter(genetics) ,  *DNA ,  carcinogenesis ,  risk factor ,  toxicology ,  acute myeloid leukemia ,  polyphenol ,  aromatic hydrocarbon
Semi thesaurus term： *過メチル化 , 【Automatic Indexing@JST】

Author keywords (5)： Benzene ,  Hydroquinone ,  HOTAIRM1 ,  DNMT3b ,  DNA methylation

JST classification (1)： Toxicity of organic compounds  (GZ02030Y)

Substance index (2)： Hydroquinone ,  Benzene

Terms in the title (12)： Dnmt3b ,  アップレギュレーション ,  ベンゼン ,  曝露 ,  ヒドロキノン ,  労働 ,  長期曝露 ,  形質転換 ,  細胞 ,  DNA ,  過メチル化 ,  サイレンシング