Art

J-GLOBAL ID：202002235337898164   Reference number：20A0531837

Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B

HCV NS5Bの汎遺伝子型非ヌクレオシド阻害剤としてのベンゾフラン誘導体の多段階並列合成による最適化【JST・京大機械翻訳】

Author (9)： Xiao Dong (Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA) ,  Dai Xing (Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA) ,  Liu Hong (Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA) ,  He Shuwen (Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA) ,  Shi Zhi-Cai (Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA) ,  Ludmerer Steven W. (Department of Biology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA) ,  Li Fangbiao (Department of Drug Metabolism, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA) ,  Nargund Ravi (Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA) ,  Palani Anandan (Department of Medicinal Chemistry, Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 30  Issue： 7  Page： Null  Publication year： 2020 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： In a lead optimization effort ...

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Thesaurus term： *Genotype ,  *optimization ,  solubility (ratio) ,  Lead ,  *nucleoside ,  Physico-chemical property ,  *Benzofurans ,  *NS5B ,  *modification

Author keywords (4)： NS5B NNI inhibitors ,  Lead optimization ,  Multi-step parallel libraries ,  Pan-genotypic potency

JST classification (2)： Synthesis of drugs  (GV01030F) ,  Structure-activity relationship of drugs  (GV01050B)

Terms in the title (8)： HCV ,  NS5B ,  遺伝子型 ,  ヌクレオシド ,  阻害剤 ,  ベンゾフラン誘導体 ,  段階 ,  最適化