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J-GLOBAL ID：202002235819030802   Reference number：20A0271410

HIF1α inhibits LPS-mediated induction of IL-6 synthesis via SOCS3-dependent CEBPβ suppression in human dental pulp cells

HIF1αはヒト歯髄細胞におけるSOCS3依存性CEBPβ抑制を介してLPS仲介IL-6合成の誘導を阻害する【JST・京大機械翻訳】

Author (10)： Fujii Mayuko (Department of Pulp Biology and Endodontics, 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8549, Japan) ,  Kawashima Nobuyuki (Department of Pulp Biology and Endodontics, 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8549, Japan) ,  Tazawa Kento (Department of Pulp Biology and Endodontics, 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8549, Japan) ,  Hashimoto Kentaro (Department of Pulp Biology and Endodontics, 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8549, Japan) ,  Nara Keisuke (Department of Pulp Biology and Endodontics, 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8549, Japan) ,  Noda Sonoko (Department of Pulp Biology and Endodontics, 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8549, Japan) ,  Kuramoto Masashi (Department of Pulp Biology and Endodontics, 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8549, Japan) ,  Orikasa Shion (Department of Pulp Biology and Endodontics, 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8549, Japan) ,  Nagai Shigenori (Department of Molecular Immunology, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8549, Japan) ,  Okiji Takashi (Department of Pulp Biology and Endodontics, 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8549, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 522  Issue： 2  Page： 308-314  Publication year： 2020 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Hypoxia-inducible factor 1 alp...

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Thesaurus term： interleukin ,  *Dental Pulp ,  *human ,  *interleukin 6 ,  Up-Regulation ,  lipopolysaccharide ,  oxygen deficiency ,  Pulpitis ,  inflammatory cytokine ,  repressor ,  ischemia ,  transcription factor ,  Down-Regulation ,  anoxia ,  Inflammation

Author keywords (6)： CEBPβ ,  hDPCs ,  HIF1α ,  Hypoxic conditions ,  IL-6 ,  SOCS3

JST classification (3)： Cell physiology in general  (EF02010S) ,  Biological function  (EB06020T) ,  Mouth(=oral cavity),esophagus  (EJ06020R)

Terms in the title (10)： HIF1α ,  ヒト ,  歯髄細胞 ,  SOCS3 ,  依存性 ,  LPS ,  仲介 ,  IL-6 ,  誘導 ,  阻害