Art

J-GLOBAL ID：202002235883485817   Reference number：20A0458090

Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice

慢性Dicer1欠損はマウスにおける萎縮性および新生血管外網膜病理を促進する【JST・京大機械翻訳】

Author (42)： Wright Charles B. (Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40506) ,  Uehara Hironori (Department of Ophthalmology, Loma Linda University, Loma Linda, CA 92350) ,  Kim Younghee (Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Kim Younghee (Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Yasuma Tetsuhiro (Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40506) ,  Yasuma Reo (Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Yasuma Reo (Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Hirahara Shuichiro (Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Hirahara Shuichiro (Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Makin Ryan D. (Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Makin Ryan D. (Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Makin Ryan D. (Molecular and Cellular Basis of Disease Graduate Program, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Apicella Ivana (Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Apicella Ivana (Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Pereira Felipe (Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Pereira Felipe (Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Pereira Felipe (Departamento de Oftalmologia e Ciencias Visuais, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo 04039-032, Brazil) ,  Nagasaka Yosuke (Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Nagasaka Yosuke (Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Narendran Siddharth (Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Narendran Siddharth (Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Narendran Siddharth (Aravind Medical Research Foundation, Aravind Eye Care System, Madurai, Tamil Nadu 625020, India) ,  Fukuda Shinichi (Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Fukuda Shinichi (Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Fukuda Shinichi (Department of Ophthalmology, University of Tsukuba, Ibaraki 305-8575, Japan) ,  Albuquerque Romulo (Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40506) ,  Fowler Benjamin J. (Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40506) ,  Bastos-Carvalho Ana (Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40506) ,  Georgel Philippe (Laboratoire d’ImmunoRhumatologie Moleculaire, INSERM UMR-S1109, LabEx Transplantex, Federation de Medecine Translationnelle de Strasbourg, Universite de Strasbourg, 67085 Strasbourg, France) ,  Georgel Philippe (Federation Hospitalo-Universitaire OMICARE, Universite de Strasbourg, 67085 Strasbourg, France) ,  Hatada Izuho (Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan) ,  Chang Bo (The Jackson Laboratory, Bar Harbor, ME 04609) ,  Kerur Nagaraj (Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Kerur Nagaraj (Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Ambati Balamurali K. (Department of Ophthalmology, Loma Linda University, Loma Linda, CA 92350) ,  Ambati Jayakrishna (Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Ambati Jayakrishna (Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Ambati Jayakrishna (Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Ambati Jayakrishna (Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Gelfand Bradley D. (Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Gelfand Bradley D. (Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22903) ,  Gelfand Bradley D. (Department of Biomedical Engineering, University of Virginia School of Engineering, Charlottesville, VA 22904)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 117  Issue： 5  Page： 2579-2587  Publication year： 2020 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Degeneration of the retinal pi...

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Thesaurus term： retinal pigment epithelium ,  homeostasis ,  angiogenesis ,  *pathological state ,  natural immunity ,  biosynthesis ,  ablation ,  vector(genetics) ,  *blood vessel ,  *atrophy(disease) ,  adapter ,  *retina ,  choroidea ,  RNase
Semi thesaurus term： MyD88 , 【Automatic Indexing@JST】

Author keywords (4)： Dicer ,  retina ,  inflammasome ,  choroidal neovascularization

JST classification (2)： Basic ophthalmology  (GP01020C) ,  Basic medicine on cardiovascular system  (GJ01020K)

Terms in the title (8)： 慢性 ,  欠損 ,  マウス ,  萎縮 ,  新生血管 ,  網膜 ,  病理 ,  促進