Art

J-GLOBAL ID：202002236251282016   Reference number：20A0748367

Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation

細胞透過性ナノ粒子は,分解のために微小管関連蛋白質1-軽鎖3を標的化することにより抗体産生を増強するためにインフラマソームを活性化する【JST・京大機械翻訳】

Author (13)： Zhu Motao (Department of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, California, United States) ,  Zhu Motao (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, China) ,  Zhu Motao (Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Texas, United States) ,  Du Libo (State Key Laboratory for Structural Chemistry of Unstable Species, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, China) ,  Zhao Ruifang (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, China) ,  Zhao Ruifang (Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Texas, United States) ,  Wang Helen Y. (Department of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, California, United States) ,  Wang Helen Y. (Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Texas, United States) ,  Zhao Yuliang (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, China) ,  Nie Guangjun (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, China) ,  Wang Rong-Fu (Department of Medicine, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, California, United States) ,  Wang Rong-Fu (Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Texas, United States) ,  Wang Rong-Fu (Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, California, United States)
Material： ACS Nano
Volume： 14  Issue： 3  Page： 3703-3717  Publication year： 2020 
JST Material Number： W2326A  ISSN： 1936-0851  CODEN： ANCAC3  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Engineered nanoparticles could...

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Thesaurus term： egg albumin ,  interleukin 1 ,  cellular signal transduction ,  NF-kappaB ,  autophagy ,  *antibody formation ,  natural immunity ,  *targeting ,  *light chain ,  *nano particle ,  *microtubule-associated protein ,  immunotherapy ,  adjuvant ,  cytoplasm ,  endocytosis

Author keywords (6)： NLRP3 inflammasome ,  cell-penetrating ultrasmall-sized gold nanoparticles ,  autophagy ,  microtubule-associated protein 1-light chain 3 (LC3) ,  adjuvant activity ,  antibody production

JST classification (3)： Experimental treatment for tumors  (GE02040Y) ,  Cell physiology in general  (EF02010S) ,  Medical materials  (GA05040H)

Terms in the title (11)： 細胞 ,  透過性 ,  ナノ粒子 ,  分解 ,  微小管関連蛋白質 ,  軽鎖 ,  標的化 ,  抗体産生 ,  増強 ,  インフラマソーム ,  活性化