Art

J-GLOBAL ID：202002237508419122   Reference number：20A0609551

A Synthetic Human Antibody Antagonizes IL-18Rβ Signaling Through an Allosteric Mechanism

合成ヒト抗体はアロステリック機構を介してIL-18Rβシグナル伝達にきっ抗する【JST・京大機械翻訳】

Author (14)： Liu Shusu (Laboratory of Antibody Engineering, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China) ,  Miersch Shane (Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada) ,  Li Ping (Laboratory of Antibody Engineering, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China) ,  Li Ping (Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, China) ,  Bai Bingxin (Laboratory of Antibody Engineering, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China) ,  Liu Chunchun (Laboratory of Antibody Engineering, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China) ,  Qin Wenming (National Facility for Protein Science (Shanghai), Shanghai Advanced Research Institute (Zhangjiang Lab), Chinese Academy of Sciences, Shanghai, China) ,  Su Jie (Laboratory of Antibody Engineering, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China) ,  Huang Haiming (Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada) ,  Huang Haiming (Shanghai Asian United Antibody Medical Co., Shanghai, China) ,  Pan James (Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada) ,  Sidhu Sachdev S. (Laboratory of Antibody Engineering, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China) ,  Sidhu Sachdev S. (Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada) ,  Wu Donghui (Laboratory of Antibody Engineering, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China)
Material： Journal of Molecular Biology  (J Mol Biol)
Volume： 432  Issue： 4  Page： 1169-1182  Publication year： 2020 
JST Material Number： D0124B  ISSN： 0022-2836  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The interleukin-18 subfamily b...

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Thesaurus term： *allosteric effect ,  NF-kappaB ,  interferon gamma ,  autoimmune disease ,  MAP kinase ,  *antibody ,  interleukin ,  adaptability ,  immunological reaction ,  cytokine receptor ,  interleukin 1 ,  *human(primates) ,  crystal structure ,  complex(substance)
Semi thesaurus term： インターロイキン18 , 【Automatic Indexing@JST】

Author keywords (5)： interleukin-1 family ,  interleukin-18 subfamily ,  IFN-γ ,  antibody phage display ,  crystal structure

JST classification (2)： Antigens,antibodies,complements in general  (ED04010A) ,  Production and application of antigens,antibodies,complements  (ED04030W)

Terms in the title (5)： ヒト ,  抗体 ,  アロステリック機構 ,  シグナル伝達 ,  きっ抗