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J-GLOBAL ID：202002237826821111   Reference number：20A0256075

胎生期卵巣におけるNR5A1/Ad4BP/SF1の転写抑制はNotchシグナルを介した卵巣発生の最適化に必要である

Author (2)： NOMURA RISA (東京医歯大 発生発達病態学) ,  KASHIMADA KEN'ICHI (東京医歯大 発生発達病態学)
Material： 日本生殖内分泌学会雑誌(Web)  (Japanese Journal of Reproductive Endocrinology (Web))
Volume： 24  Page： 18-23 (WEB ONLY)  Publication year： Aug. 31, 2019 
JST Material Number： U1815A  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *Sex Differentiation ,...
Semi thesaurus term： *genetic regulation ,...

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JST classification (6)： Reproductive(=genital)organs  (EJ15020P) ,  Development(=generation)and differentiation  (EJ16020W) ,  Gene expression  (EC02040Q) ,  Cell physiology in general  (EF02010S) ,  Basic gynecology and obstetrics  (GS01020L) ,  Basic medicine on urogenital system  (GM01020T)

Reference (17)：

• Honda S, Morohashi K, Nomura M, Takeya H, Kitajima M, and Omura T(1993)Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily. J Biol Chem268, 7494-7502.
• Luo X, Ikeda Y, and Parker K. L(1994)A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77, 481-490.
• Hanley N. A, Ball S. G, Clement-Jones M, Hagan D. M, Strachan T, Lindsay S, Robson S, Ostrer H, Parker K. L, and Wilson D. I(1999)Expression of steroidogenic factor 1 and Wilms’ tumour 1 during early human gonadal development and sex determination. Mech Dev 87, 175-180.
• Sekido R, and Lovell-Badge R(2008)Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer. Nature 453, 930-934.
• Buaas F. W, Gardiner J. R, Clayton S, Val P, and Swain, A(2012)In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland. Development 139, 4561-4570.

Terms in the title (5)： 胎生期 ,  卵巣 ,  転写抑制 ,  Notchシグナル ,  最適化