Art

J-GLOBAL ID：202002238302518501   Reference number：20A0200332

Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands

糖共役TLR7リガンドの合成と免疫賦活活性【JST・京大機械翻訳】

Author (10)： Baba Akihito (Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan) ,  Wakao Masahiro (Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan) ,  Shinchi Hiroyuki (Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan) ,  Chan Michael (Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0695, USA) ,  Hayashi Tomoko (Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0695, USA) ,  Yao Shiyin (Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0695, USA) ,  Cottam Howard B. (Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0695, USA) ,  Carson Dennis A. (Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0695, USA) ,  Suda Yasuo (Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan) ,  Suda Yasuo (SUDx-Biotec Corporation, 1-41-1 Shiroyama, Kagoshima 890-0013, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 30  Issue： 3  Page： Null  Publication year： 2020 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Toll-like receptors (TLRs) are...

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Thesaurus term： small molecule ,  natural immunity ,  targeting ,  *immunopotentiative action ,  pathogen ,  Endocytosis ,  human ,  Toll like receptor ,  *conjugation ,  hydrophilicity ,  Endosomes ,  infectious disease ,  conjugation (metabolism) ,  low molecular weight ,  glycoconjugate ,  membrane and film ,  biomembrane ,  Endomembrane system ,  Vesicles

Author keywords (4)： TLR7 ,  Ligand ,  Agonist ,  Sugar conjugate

JST classification (1)： Synthesis of drugs  (GV01030F)

Terms in the title (5)： 糖 ,  共役 ,  TLR7 ,  リガンド ,  免疫賦活活性