Art

J-GLOBAL ID：202002238814269820   Reference number：20A1608109

Therapeutic Application of Small Extracellular Vesicles (sEVs): Pharmaceutical and Pharmacokinetic Challenges

小細胞外小胞(sEV)の治療適用:製薬的および薬物動態学的課題

Author (3)： Takakura Yoshinobu (Graduate School of Pharmaceutical Sciences, Kyoto University) ,  Matsumoto Akihiro (Graduate School of Pharmaceutical Sciences, Kyoto University) ,  Takahashi Yuki (Graduate School of Pharmaceutical Sciences, Kyoto University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 43  Issue： 4  Page： 576-583(J-STAGE)  Publication year： 2020 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cell component ,...
Semi thesaurus term： *Exosomes ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=20A1608109&from=J-GLOBAL&jstjournalNo=U1402A") }}

Author keywords (10)： exosome ,  small extracellular vesicle (sEV) ,  therapeutic application ,  pharmaceutical challenge ,  pharmacokinetic challenge ,  exosome ,  small extracellular vesicle (sEV) ,  therapeutic application ,  pharmaceutical challenge ,  pharmacokinetic challenge

JST classification (2)： Function of cell components  (EF03060C) ,  Basic biopharmacy  (GY01021U)

Reference (66)：

• 1) Théry C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat. Rev. Immunol., 9, 581-593 (2009).
• 2) Bakhshandeh B, Kamaleddin MA, Aalishah K. A comprehensive review on exosomes and microvesicles as epigenetic factors. Curr. Stem Cell Res. Ther., 12, 31-36 (2017).
• 3) Johnstone RM, Adam M, Hammond JR, Orr L, Turbide C. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J. Biol. Chem., 262, 9412-9420 (1987).
• 4) Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol., 9, 654-659 (2007).
• 5) Wiklander OPB, Brennan MA, Lotvall J, Breakefield XO, El Andaloussi S. Advances in therapeutic applications of extracellular vesicles. Sci. Transl. Med., 11, eaav8521 (2019).

Terms in the title (3)： 細胞外小胞 ,  治療適用 ,  薬物動態学