Art

J-GLOBAL ID：202002239599281125   Reference number：20A1627978

RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase

hnRNP KのRNA結合モチーフは活性化誘導シチジンデアミナーゼによる抗体多様化の誘導に重要である【JST・京大機械翻訳】

Author (7)： Yin Ziwei (Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Kobayashi Maki (Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Hu Wenjun (Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Higashi Koichi (Center for Information Biology, National Institute of Genetics, Mishima, 411-8540 Shizuoka, Japan) ,  Begum Nasim A. (Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan) ,  Kurokawa Ken (Center for Information Biology, National Institute of Genetics, Mishima, 411-8540 Shizuoka, Japan) ,  Honjo Tasuku (Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 117  Issue： 21  Page： 11624-11635  Publication year： 2020 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Activation-induced cytidine de...

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Thesaurus term： interaction ,  enzyme ,  *RNA ,  *antibody ,  ribonucleoprotein ,  diversification ,  translocation (genetics) ,  homology (characteristic) ,  prototype ,  *Heterogeneous-Nuclear Ribonucleoproteins ,  domain structure ,  protein-protein interaction ,  class switch recombination ,  DNA Cleavage ,  *RNA binding ,  cellular genetic phenomenon ,  action and behavior

Author keywords (5)： activation-induced cytidine deaminase ,  heterogeneous nuclear ribonucleoprotein K ,  RNA-binding motifs ,  DNA breaks ,  IgH

JST classification (2)： Biochemistry of antigens,antibodies,complements  (ED04020L) ,  Molecular genetics in general  (EC02010J)

Terms in the title (6)： hnRNP ,  RNA結合モチーフ ,  活性化誘導シチジンデアミナーゼ ,  抗体 ,  多様化 ,  誘導