Art

J-GLOBAL ID：202002240085496195   Reference number：20A0765832

A platform for context-specific genetic engineering of recombinant protein production by CHO cells

CHO細胞による組換え蛋白質生産の文脈特異的遺伝子工学のためのプラットフォーム【JST・京大機械翻訳】

Author (16)： Cartwright Joseph F. (Advanced Biomanufacturing Centre, Department of Chemical and Biological Engineering, University of Sheffield, Mappin St., Sheffield S1 3JD, UK) ,  Arnall Claire L. (Advanced Biomanufacturing Centre, Department of Chemical and Biological Engineering, University of Sheffield, Mappin St., Sheffield S1 3JD, UK) ,  Patel Yash D. (Advanced Biomanufacturing Centre, Department of Chemical and Biological Engineering, University of Sheffield, Mappin St., Sheffield S1 3JD, UK) ,  Barber Nicholas O.W. (Advanced Biomanufacturing Centre, Department of Chemical and Biological Engineering, University of Sheffield, Mappin St., Sheffield S1 3JD, UK) ,  Lovelady Clare S. (Biopharmaceutical Development, AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK) ,  Rosignoli Guglielmo (Antibody Discovery and Protein Engineering, AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK) ,  Harris Claire L. (Biopharmaceutical Development, AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK) ,  Dunn Sarah (Biopharmaceutical Development, AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK) ,  Field Ray P. (Biopharmaceutical Development, AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK) ,  Dean Greg (Biopharmaceutical Development, AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK) ,  Daramola Olalekan (Biopharmaceutical Development, AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK) ,  Gibson Suzanne J. (Biopharmaceutical Development, AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK) ,  Peden Andrew A. (Department of Biomedical Sciences, University of Sheffield, Sheffield, UK) ,  Brown Adam J. (Advanced Biomanufacturing Centre, Department of Chemical and Biological Engineering, University of Sheffield, Mappin St., Sheffield S1 3JD, UK) ,  Hatton Diane (Biopharmaceutical Development, AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK) ,  James David C. (Advanced Biomanufacturing Centre, Department of Chemical and Biological Engineering, University of Sheffield, Mappin St., Sheffield S1 3JD, UK)
Material： Journal of Biotechnology  (Reviews in Molecular Biotechnology)
Volume： 312  Page： 11-22  Publication year： 2020 
JST Material Number： A0456C  ISSN： 0168-1656  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： An increasing number of engine...

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Thesaurus term： *CHO cell ,  *Proteins ,  monoclonal antibody ,  gene manipulation ,  Workflow ,  *recombinant protein ,  stoichiometry ,  *gene ,  multiplex ,  optimization ,  *Heredity ,  gene expression ,  production process (control) ,  Cell Engineering ,  mammalian cell ,  modification ,  molecular genetic phenomenon

Author keywords (5)： CHO ,  Cell engineering ,  High-throughput screening ,  Stable gene expression (SGE) ,  Transient gene expression (TGE)

JST classification (3)： Animal biochemistry  (EJ01050P) ,  Gene manipulation  (EC02050B) ,  Gene expression  (EC02040Q)

Terms in the title (5)： CHO細胞 ,  組換え蛋白質 ,  文脈 ,  遺伝子工学 ,  プラットフォーム