Art

J-GLOBAL ID：202002241772889030   Reference number：20A0501685

Generation of Cellular Reactive Oxygen Species by Activation of the EP2 Receptor Contributes to Prostaglandin E2-Induced Cytotoxicity in Motor Neuron-Like NSC-34 Cells

EP2受容体の活性化による細胞活性酸素種の生成は運動ニューロン様NSC-34細胞におけるプロスタグランジンE2誘導細胞毒性に寄与する【JST・京大機械翻訳】

Author (9)： Kosuge Yasuhiro (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan) ,  Nango Hiroshi (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan) ,  Kasai Hiroki (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan) ,  Yanagi Takuya (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan) ,  Mawatari Takayuki (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan) ,  Nishiyama Kenta (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan) ,  Miyagishi Hiroko (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan) ,  Ishige Kumiko (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan) ,  Ito Yoshihisa (Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan)
Material： Oxidative Medicine and Cellular Longevity (Web)  (Oxidative Med Cell Longev (Web))
Volume： 2020  Page： Null  Publication year： 2020 
JST Material Number： U7012A  ISSN： 1942-0900  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Amyotrophic lateral sclerosis ...

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Thesaurus term： *neuron ,  differentiation (biology) ,  oxidative stress ,  *motor nerve ,  neurotoxicity ,  *cytotoxicity ,  *active oxygen ,  Western blotting ,  Inflammation ,  Death ,  Cell Death ,  Central Nervous System ,  human ,  *receptor ,  Signal Transduction ,  bioassay
Semi thesaurus term： cellular signal transduction , 【Automatic Indexing@JST】

JST classification (1)： Cell physiology in general  (EF02010S)

Reference (39)：

• J. Liu, F. Wang, "Role of neuroinflammation in amyotrophic lateral sclerosis: cellular mechanisms and therapeutic implications," Frontiers in Immunology, vol. 8, pp. 1005, 2017.
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• L. Ferraiuolo, J. Kirby, A. J. Grierson, M. Sendtner, P. J. Shaw, "Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis," Nature Reviews. Neurology, vol. 7, no. 11, pp. 616-630, 2011.
• R. S. Peebles Jr., "Prostaglandins in asthma and allergic diseases," Pharmacology & Therapeutics, vol. 193, pp. 1-19, 2019.
• E. Ricciotti, G. A. FitzGerald, "Prostaglandins and inflammation," Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 31, no. 5, pp. 986-1000, 2011.

Terms in the title (9)： EP2受容体 ,  活性化 ,  細胞 ,  活性酸素種 ,  運動ニューロン ,  NSC-34細胞 ,  プロスタグランジンE2 ,  誘導 ,  細胞毒性