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J-GLOBAL ID：202002242420462351   Reference number：20A0138034

Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15

666-15によるcAMP応答エレメント結合蛋白質(CREB)仲介遺伝子転写の相乗的阻害剤の発見【JST・京大機械翻訳】

Author (5)： Xie Fuchun (Program in Chemical Biology, Department of Chemical Physiology and Biochemistry, Oregon Health & Science University) ,  Fan Qiuhua (Program in Chemical Biology, Department of Chemical Physiology and Biochemistry, Oregon Health & Science University) ,  Li Bingbing X. (Program in Chemical Biology, Department of Chemical Physiology and Biochemistry, Oregon Health & Science University) ,  Xiao Xiangshu (Program in Chemical Biology, Department of Chemical Physiology and Biochemistry, Oregon Health & Science University) ,  Xiao Xiangshu (Knight Cancer Institute, Oregon Health & Science University)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 62  Issue： 24  Page： 11423-11429  Publication year： 2019 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： CREB is a transcription factor...

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Thesaurus term： small molecule ,  pathogenesis ,  *CRE binding protein ,  transcription factor ,  ester ,  water solubility ,  prodrug
Semi thesaurus term： 阻害活性 ,  癌治療 , 【Automatic Indexing@JST】

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Terms in the title (6)： cAMP応答エレメント結合蛋白質 ,  CREB ,  仲介 ,  遺伝子転写 ,  阻害剤 ,  発見