Art

J-GLOBAL ID：202002242546267763   Reference number：20A0502955

miR-221 Augments TRAIL-Mediated Apoptosis in Prostate Cancer Cells by Inducing Endogenous TRAIL Expression and Targeting the Functional Repressors SOCS3 and PIK3R1

miR-221は内因性TRAIL発現を誘導し,機能的レプレッサーSOCS3とPIK3R1を標的とすることにより前立腺癌細胞におけるTRAIL仲介アポトーシスを増強する【JST・京大機械翻訳】

Author (13)： Krebs Markus (Department of Urology and Paediatric Urology, University Hospital Wuerzburg, Wuerzburg, Germany) ,  Krebs Markus (Else Kroner Integrative Clinician Scientist College for Translational Immunology, University Hospital Wuerzburg, Wuerzburg, Germany) ,  Behrmann Christoph (Department of Urology and Paediatric Urology, University Hospital Wuerzburg, Wuerzburg, Germany) ,  Kalogirou Charis (Department of Urology and Paediatric Urology, University Hospital Wuerzburg, Wuerzburg, Germany) ,  Sokolakis Ioannis (Department of Urology and Paediatric Urology, University Hospital Wuerzburg, Wuerzburg, Germany) ,  Kneitz Susanne (Physiological Chemistry, University of Wuerzburg, Biocentre, Wuerzburg, Germany) ,  Kruithof-de Julio Marianna (Urology Research Laboratory, Department of Biomedical Research, University of Bern, Bern, Switzerland) ,  Zoni Eugenio (Urology Research Laboratory, Department of Biomedical Research, University of Bern, Bern, Switzerland) ,  Rech Anne (Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, Wuerzburg, Germany) ,  Schilling Bastian (Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, Wuerzburg, Germany) ,  Kuebler Hubert (Department of Urology and Paediatric Urology, University Hospital Wuerzburg, Wuerzburg, Germany) ,  Spahn Martin (Urology Hirslanden Zuerich, Zuerich, Switzerland) ,  Kneitz Burkhard (Department of Urology and Paediatric Urology, University Hospital Wuerzburg, Wuerzburg, Germany)
Material： BioMed Research International (Web)  (BioMed Res Int (Web))
Volume： 2019  Page： Null  Publication year： 2019 
JST Material Number： U7008A  ISSN： 2314-6133  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： miR-221 is regarded as an onco...

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Thesaurus term： interferon ,  sensitization(immunology) ,  *prostatic tumor ,  carcinogenicity ,  *apoptosis ,  gene ,  inhibition of multiplication ,  siRNA ,  down-regulation ,  oncogene ,  *repressor ,  sensitivity ,  Western blotting
Semi thesaurus term： *TNF関連アポトーシス誘導リガンド ,  *内因性 , 【Automatic Indexing@JST】

JST classification (3)： Experimental treatment for tumors  (GE02040Y) ,  Cell physiology in general  (EF02010S) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (45)：

• T. Gura, "How TRAIL kills cancer cells, but not normal cells," Science, vol. 277, no. 5327, pp. 768-768, 1997.
• D. W. Stuckey, K. Shah, "TRAIL on trial: preclinical advances in cancer therapy," Trends in Molecular Medicine, vol. 19, no. 11, pp. 685-694, 2013.
• C. T. Hellwig, M. Rehm, "TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapies," Molecular Cancer Therapeutics, vol. 11, no. 1, pp. 3-13, 2012.
• J. Lemke, S. Von Karstedt, J. Zinngrebe, H. Walczak, "Getting TRAIL back on track for cancer therapy," Cell Death & Differentiation, vol. 21, no. 9, pp. 1350-1364, 2014.
• T. Lu, N. Shao, C. Ji, "Targeting microRNAs to modulate TRAIL-induced apoptosis of cancer cells," Cancer Gene Therapy, vol. 20, no. 1, pp. 33-37, 2013.

Terms in the title (12)： miR-221 ,  内因性 ,  TRAIL ,  発現 ,  誘導 ,  レプレッサー ,  SOCS3 ,  標的 ,  前立腺癌細胞 ,  仲介 ,  アポトーシス ,  増強