Art

J-GLOBAL ID：202002243319514567   Reference number：20A0610610

IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways

IL-13およびIL-4は単離ヒト小気道における過敏性を誘導するが,IL-5はIL-17Aではない【JST・京大機械翻訳】

Author (19)： Manson Martijn L. (Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden) ,  Manson Martijn L. (Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden) ,  Manson Martijn L. (Bioscience, Respiratory, Inflammation and Autoimmunity (RIA), IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden) ,  Saefholm Jesper (Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden) ,  Saefholm Jesper (Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden) ,  James Anna (Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden) ,  James Anna (Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden) ,  Johnsson Anna-Karin (Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden) ,  Johnsson Anna-Karin (Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden) ,  Bergman Per (Department of Molecular Medicine and Surgery (MMK), Karolinska Institutet, Stockholm, Sweden) ,  Bergman Per (Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden) ,  Al-Ameri Mamdoh (Department of Molecular Medicine and Surgery (MMK), Karolinska Institutet, Stockholm, Sweden) ,  Al-Ameri Mamdoh (Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, Stockholm, Sweden) ,  Orre Ann-Charlotte (Department of Molecular Medicine and Surgery (MMK), Karolinska Institutet, Stockholm, Sweden) ,  Kaerrman-Mardh Carina (Bioscience, Respiratory, Inflammation and Autoimmunity (RIA), IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden) ,  Dahlen Sven-Erik (Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden) ,  Dahlen Sven-Erik (Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden) ,  Adner Mikael (Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden) ,  Adner Mikael (Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden)
Material： Journal of Allergy and Clinical Immunology  (J Allergy Clin Immunol)
Volume： 145  Issue： 3  Page： 808-817.e2  Publication year： 2020 
JST Material Number： A0182B  ISSN： 0091-6749  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Specific inflammatory pathways...

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Thesaurus term： *interleukin 5 ,  bronchoconstrictor ,  cytokine ,  *interleukin 4 ,  Inflammation ,  receptor ,  *human ,  targeting ,  antagonism ,  Up-Regulation ,  bronchus ,  asthma ,  *air duct (respiration) ,  RNA ,  glucocorticoid

Author keywords (9)： Airway smooth muscle ,  airway hyperresponsiveness ,  bronchoconstriction explanted human tissue model ,  calcium signaling ,  bronchoconstrictor agents ,  IL-4Rα ,  dupilumab ,  glucocorticoid ,  STAT6

JST classification (2)： Basic medicine on respiratory system  (GI01020H) ,  Respiratory system diseases  (GI03000Z)

Terms in the title (9)： IL-13 ,  IL-4 ,  単離 ,  ヒト ,  気道 ,  過敏性 ,  誘導 ,  IL-5 ,  IL-17A