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J-GLOBAL ID：202002243599679138   Reference number：20A0503066

Role of Metformin on Osteoblast Differentiation in Type 2 Diabetes

2型糖尿病における骨芽細胞分化に対するメトホルミンの役割【JST・京大機械翻訳】

Author (3)： Jiating Lin ( Department of Stomatology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province 241000, China) ,  Buyun Ji ( Department of Stomatology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province 241000, China) ,  Yinchang Zhang ( Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province 241000, China)
Material： BioMed Research International (Web)  (BioMed Res Int (Web))
Volume： 2019  Page： Null  Publication year： 2019 
JST Material Number： U7008A  ISSN： 2314-6133  Document type： Article
Article type： 文献レビュー  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Metformin, an effective hypogl...

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Thesaurus term： Cell Membrane ,  osteoporosis ,  ERK ,  Mitochondria ,  serum concentration ,  osteoclast ,  Collagen ,  transcription factor ,  lysosome ,  insulin ,  *osteoblast ,  *Type 2 diabetes mellitus ,  osteogenesis ,  anti-inflammatory action ,  phosphorylation ,  Endomembrane system ,  Scleroproteins ,  animal protein ,  hypoglycemic drug ,  metabolic drug ,  carbohydrate metabolic drug ,  drug

JST classification (2)： Cell physiology in general  (EF02010S) ,  Skeletal system  (EJ10030R)

Reference (79)：

• C. A. Bannister, S. E. Holden, S. Jenkins-Jones et al., "Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls," Diabetes, Obesity and Metabolism, vol. 16, no. 11, pp. 1165-1173, 2014.
• R. A. Defronzo, A. M. Goodman, "Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus," New England Journal of Medicine, vol. 333, no. 9, pp. 541-549, 1995.
• S. Bajaj, "RSSDI clinical practice recommendations for the management of type 2 diabetes mellitus 2017," International Journal of Diabetes in Developing Countries, vol. 38, no. S1, pp. 1-115, 2018.
• J. M. Campbell, S. M. Bellman, M. D. Stephenson, K. Lisy, "Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: a systematic review and meta-analysis," Ageing Research Reviews, vol. 40, pp. 31-44, 2017.
• G. Rena, D. G. Hardie, E. R. Pearson, "The mechanisms of action of metformin," Diabetologia, vol. 60, no. 9, pp. 1577-1585, 2017.

Terms in the title (4)： 2型糖尿病 ,  骨芽細胞分化 ,  メトホルミン ,  役割