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J-GLOBAL ID：202002244705211830   Reference number：20A1118934

Pharmacological Mechanism of the Development of Dependence on Benzodiazepine-receptor Agonists

ベンゾジアゼピン受容体作動薬の問題点と適正使用 ベンゾジアゼピン受容体作動薬依存の薬理学的機序

Author (3)： SHIBASAKI MASAHIRO (星薬大) ,  MORI TOMOHISA (星薬大) ,  NARITA MINORU (星薬大)
Material： 精神医学  (Clinical Psychiatry)
Volume： 62  Issue： 4  Page： 387-394  Publication year： Apr. 15, 2020 
JST Material Number： Z0446B  ISSN： 0488-1281  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *benzodiazepine antianxiety drug ,...
Semi thesaurus term： GABAA受容体α1サブユニット ,...

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JST classification (1)： Basic research of psychotropic drugs  (GW03100Y)

Substance index (1)： Zolpidem

Reference (24)：

• Sieghart W, Sperk G : Subunit composition, distribution and function of GABA (A) receptor subtypes. Curr Top Med Chem 2 : 795-816, 2002
• Jacob TC, Moss SJ, Jurd R : GABA (A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nat Rev Neurosci 9 : 331-343, 2008
• Fritschy JM, Mohler H : GABAA-receptor heterogeneity in the adult rat brain ; differential regional and cellular distribution of seven major subunits. J Comp Neurol 359 : 154-194, 1995
• Sieghart W : GABAA receptors ; ligand-gated Cl-ion channels modulated by multiple drug-binding sites. Trends Pharmacol Sci 13 : 446-450, 1992
• Study RE, Barker JL : Diazepam and pentobarbital : fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons. Proc Natl Acad Sci USA 78 : 7180-7184, 1981

Terms in the title (4)： ベンゾジアゼピン受容体作動薬 ,  問題点 ,  適正使用 ,  薬理学