Art

J-GLOBAL ID：202002244856010567   Reference number：20A0764479

Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease

腎臓TNFαは慢性腎臓病におけるWNKリン酸化カスケードを活性化し,食塩感受性高血圧症に寄与する【JST・京大機械翻訳】

Author (18)： Furusho Taisuke (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Sohara Eisei (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Mandai Shintaro (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Kikuchi Hiroaki (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Takahashi Naohiro (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Fujimaru Takuya (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Hashimoto Hiroko (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Arai Yohei (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Ando Fumiaki (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Zeniya Moko (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Mori Takayasu (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Susa Koichiro (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Isobe Kiyoshi (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Nomura Naohiro (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Yamamoto Kohei (Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Okado Tomokazu (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Rai Tatemitsu (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) ,  Uchida Shinichi (Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan)
Material： Kidney International  (Kidney Int)
Volume： 97  Issue： 4  Page： 713-727  Publication year： 2020 
JST Material Number： E0559B  ISSN： 0085-2538  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The inappropriate over-activat...

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Thesaurus term： convolution ,  Sodium ,  *Hypertension ,  Proteins ,  kidney tubule ,  Nephrosis ,  nephron ,  ligase ,  *phosphorylation ,  Up-Regulation ,  *TNF alpha ,  *Chronic kidney disease ,  Immune System ,  protein expression ,  nitrogen heterocyclic compound

Author keywords (5)： chronic kidney disease ,  hypertension ,  NaCl cotransporter ,  TNFα ,  WNK kinase

JST classification (2)： Basic medicine on urogenital system  (GM01020T) ,  Transport of cell membrane  (EF04020R)

Substance index (1)： Adenine

Terms in the title (7)： 腎臓 ,  TNFα ,  慢性腎臓病 ,  リン酸化 ,  カスケード ,  活性化 ,  食塩感受性高血圧症