Art

J-GLOBAL ID：202002246274355812   Reference number：20A0026248

Tong-Xie-Yao-Fang improves intestinal permeability in diarrhoea-predominant irritable bowel syndrome rats by inhibiting the NF-κB and notch signalling pathways

Tong-Xie-Yao-Fangは,NF-κBおよびNotchシグナル伝達経路を阻害することにより下痢症-優性過敏性腸症候群ラットにおける腸透過性を改善する【JST・京大機械翻訳】

Author (8)： Hou Qiuke (Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China) ,  Hou Qiuke (School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China) ,  Huang Yongquan (Department of Orthopaedics, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China) ,  Zhu Zhaoyang (Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China) ,  Liao Liu (Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China) ,  Chen Xinlin (Department of Preventive Medicine and Health Statistics, Guangzhou University of Chinese Medicine, Guangzhou, China) ,  Han Quanbin (School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China) ,  Liu Fengbin (Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China)
Material： BMC Complementary and Alternative Medicine (Web)
Volume： 19  Issue： 1  Page： 1-10  Publication year： 2019 
JST Material Number： U7420A  ISSN： 1472-6882  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Tong-Xie-Yao-Fang (TXYF) has b...

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Thesaurus term： inflammation ,  down-regulation ,  *NF-kappaB ,  defecation ,  up-regulation ,  epithelial cell ,  colon ,  *diarrhea ,  intestinal mucosa ,  *Notch receptor ,  TNF alpha ,  edema ,  *rat ,  chemokine ,  Western blotting

Author keywords (5)： Tong-Xie-Yao-fang ,  Diarrhoea predominant-irritable bowel syndrome ,  Intestinal permeability ,  NF-κB Signalling ,  Notch Signalling

JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic research of anti-inflammatory drugs  (GW15010T)

Reference (32)：

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• PLoS One; Berberine improves intestinal motility and visceral pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome (IBS-D) symptoms in an opioid-receptor dependent manner; C Chen, M Lu, Q Pan; 10; 12; 2015; 10.1371/journal.pone.0145556; citation_id=CR2
• J Neurogastroenterol Motility; MicroRNA-200a targets cannabinoid receptor 1 and serotonin transporter to increase visceral Hyperalgesia in diarrhea-predominant irritable bowel syndrome rats; Q Hou, Y Huang, C Zhang; 24; 4; 2018; 656-668; 10.5056/jnm18037; citation_id=CR3
• Cell Physiol Biochem; MiR-144 increases intestinal permeability in IBS-D rats by targeting OCLN and ZO1; Q Hou, Y Huang, S Zhu; 44; 6; 2017; 2256-2268; 10.1159/000486059; citation_id=CR4
• Gut.; Hemidesmosome integrity protects the colon against colitis and colorectal cancer; A Arcangelis, H Hamade, F Alpy; 66; 10; 2017; 1748-1760; 10.1136/gutjnl-2015-310847; citation_id=CR5

Terms in the title (9)： NF-κB ,  Notchシグナル ,  伝達経路 ,  阻害 ,  下痢症 ,  優性 ,  過敏性腸症候群 ,  ラット ,  腸透過性