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J-GLOBAL ID：202002246581450717   Reference number：20A1209312

A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling

PINK1-Parkinシグナル伝達を増強する2つの化合物を同定した細胞に基づくハイスループットスクリーニング【JST・京大機械翻訳】

Author (13)： Shiba-Fukushima Kahori (Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan) ,  Inoshita Tsuyoshi (Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan) ,  Sano Osamu (BioMolecular Research Laboratories, Takeda Pharmaceutical Company, Fujisawa, Kanagawa 251-8555, Japan) ,  Iwata Hidehisa (BioMolecular Research Laboratories, Takeda Pharmaceutical Company, Fujisawa, Kanagawa 251-8555, Japan) ,  Ishikawa Kei-ichi (Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan) ,  Ishikawa Kei-ichi (Department of Neurology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Okano Hideyuki (Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan) ,  Akamatsu Wado (Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan) ,  Imai Yuzuru (Department of Neurology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Imai Yuzuru (Department of Research for Parkinson’s Disease, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Hattori Nobutaka (Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan) ,  Hattori Nobutaka (Department of Neurology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Hattori Nobutaka (Department of Research for Parkinson’s Disease, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan)
Material： iScience
Volume： 23  Issue： 5  Page： Null  Publication year： 2020 
JST Material Number： W5512A  ISSN： 2589-0042  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Early-onset Parkinson’s diseas...

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Thesaurus term： aggregation ,  mitochondria ,  deconvolution ,  Drosophila ,  small molecule ,  robustness ,  Parkinson's disease ,  *cellular signal transduction ,  myoblast
Semi thesaurus term： ミトコンドリア蛋白質 ,  *ハイスループットスクリーニングアッセイ ,  *Parkin ,  ドーパミン作動性ニューロン ,  ミトコンドリア機能 , 【Automatic Indexing@JST】

Author keywords (3)： Biological Sciences ,  Neuroscience ,  Cell Biology

JST classification (2)： Basic neurology  (GN01020W) ,  Function of cell components  (EF03060C)

Terms in the title (7)： PINK1 ,  Parkin ,  シグナル伝達 ,  増強 ,  同定 ,  細胞 ,  ハイスループットスクリーニング