Art

J-GLOBAL ID：202002246661033374   Reference number：20A0501200

The Herb-Drug Pharmacokinetic Interaction of Fluoxetine and Its Metabolite Norfluoxetine with a Traditional Chinese Medicine in Rats by LC-MS/MS

LC-MS/MSによるラットにおけるフルオキセチンおよびその代謝産物ノルフルオキセチンと伝統的漢方薬とのハーブ-薬物動態学的相互作用【JST・京大機械翻訳】

Author (11)： Yan Lijing ( Laboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China) ,  Wang Sheng ( Laboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China) ,  Wang Sheng ( The Second Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang 310053, China) ,  Zhao Linlin ( Department of Health Management, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China) ,  Qiu Juan ( Department of Nuclear Medicine, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410008, China) ,  Zhou Lu ( Laboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China) ,  Wang Wenbo ( Laboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China) ,  Xu Xia ( Laboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China) ,  Wang Dongsheng ( Laboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China) ,  Qiu Xinjian ( Laboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China) ,  Qin Dilan ( Environmental Monitoring Centre of Hunan Province, State Environmental Protection Key Laboratory of Monitoring for Heavy Metal Pollutants, Changsha, Hunan 410019, China)
Material： Evidence-Based Complementary and Alternative Medicine (Web)
Volume： 2019  Page： Null  Publication year： 2019 
JST Material Number： U7703A  ISSN： 1741-427X  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Background. Fluoxetine (FLU) i...

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Thesaurus term： *rat ,  *metabolite ,  *Chinese drug ,  depression(symptom) ,  serum ,  multiplex ,  liquid-liquid extraction ,  plasma concentration ,  side effect ,  adult(development) ,  clearance ,  *herb ,  depression(disease) ,  drug therapy ,  organofluorine compound ,  phenol ether ,  secondary amine

JST classification (1)： Basic research of psychotropic drugs  (GW03100Y)

Substance index (1)： Fluoxetine

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Terms in the title (8)： LC-MS ,  ラット ,  フルオキセチン ,  代謝産物 ,  ノルフルオキセチン ,  漢方薬 ,  ハーブ ,  薬物動態学的相互作用