Art

J-GLOBAL ID：202002247057054664   Reference number：20A1328435

Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3′-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1)

チロシル-DNAホスホジエステラーゼ2(TDP2)はチロシル-DNAホスホジエステラーゼ1(TDP1)の不在下でトポイソメラーゼ1 DNA-蛋白質架橋と3σ-ブロッキング病変を修復する【JST・京大機械翻訳】

Author (6)： Tsuda Masataka (Program of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima 739-8526, Japan) ,  Kitamasu Kaito (Program of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima 739-8526, Japan) ,  Kumagai Chiho (Program of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima 739-8526, Japan) ,  Sugiyama Kazuya (Program of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima 739-8526, Japan) ,  Nakano Toshiaki (DNA Damage Chemistry Research Group, Institute for Quantum Life Science, National Institutes of Quantum and Radiological Science and Technology, 8-1-7 Umemidai, Kizugawa-shi, Kyoto 619-0215, Japan) ,  Ide Hiroshi (Program of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima 739-8526, Japan)
Material： DNA Repair
Volume： 91-92  Page： Null  Publication year： 2020 
JST Material Number： W1339A  ISSN： 1568-7864  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Topoisomerase I (TOP1) resolve...

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Thesaurus term： peptide ,  *DNA ,  antitumor drug ,  *protein ,  *phosphodiesterase ,  active site ,  complex(substance) ,  *blocking effect ,  wild type ,  monoclonal antibody ,  DNA lesion ,  proteasome ,  lactam ,  lactone ,  hydroxy compound ,  polynuclear aromatic compound ,  halogeno sugar ,  riboside
Semi thesaurus term： *トポイソメラーゼ , 【Automatic Indexing@JST】

Author keywords (6)： Topoisomerase I (TOP1) ,  Proteasome ,  Tyrosyl-DNA phosphodiesterase 1 (TDP1) ,  Tyrosyl-DNA phosphodiesterase 2 (TDP2) ,  Camptothecin ,  3′-blocking lesions

JST classification (1)： Molecular genetics in general  (EC02010J)

Substance index (2)： Camptothecin ,  Gemcitabine

Terms in the title (8)： DNA ,  ホスホジエステラーゼ ,  トポイソメラーゼ ,  蛋白質 ,  架橋 ,  ブロッキング ,  病変 ,  修復