Art

J-GLOBAL ID：202002247921032050   Reference number：20A0298454

In silico and in vitro studies of two non-imidazole multiple targeting agents at histamine H₃ receptors and cholinesterase enzymes

ヒスタミンH_3受容体およびコリンエステラーゼ酵素における2つの非イミダゾール多重標的剤のin silicoおよびin vitro研究【JST・京大機械翻訳】

Author (12)： Ghamari Nakisa (Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran) ,  Ghamari Nakisa (School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran) ,  Dastmalchi Siavoush (Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran) ,  Dastmalchi Siavoush (School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran) ,  Zarei Omid (Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran) ,  Zarei Omid (Neurosciences Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran) ,  Arias-Montano Jose-Antonio (Departamento de Fisiologia, Biofisica y Neurociencias, Centro de Investigacion y de EstudiosAvanzados del IPN, Ciudad de Mexico, Mexico) ,  Reiner David (Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Duesseldorf, Duesseldorf, Germany) ,  Ustun-Alkan Fulya (Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey) ,  Stark Holger (Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Duesseldorf, Duesseldorf, Germany) ,  Hamzeh-Mivehroud Maryam (Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran) ,  Hamzeh-Mivehroud Maryam (School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran)
Material： Chemical Biology & Drug Design  (Chem Biol Drug Des)
Volume： 95  Issue： 2  Page： 279-290  Publication year： 2020 
JST Material Number： A1436A  ISSN： 1747-0277  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Recently, multi-target directe...

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Thesaurus term： pathophysiology ,  antagonism ,  optimization ,  *multiplex ,  drug therapy ,  *enzyme ,  lead ,  affinity ,  biological activity ,  lead compound ,  *in vitro experiment ,  Alzheimer disease ,  *cholinesterase ,  *receptor
Semi thesaurus term： *in silico , 【Automatic Indexing@JST】

Author keywords (6)： anticholinesterase ,  anti-H3R agents ,  histamine H3 receptor ,  molecular docking ,  molecular dynamics simulation ,  multi-target directed ligands

JST classification (2)： Synthesis of drugs  (GV01030F) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Terms in the title (8)： ヒスタミン ,  受容体 ,  コリンエステラーゼ ,  酵素 ,  イミダゾール ,  多重 ,  標的 ,  研究