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J-GLOBAL ID：202002248051607951   Reference number：20A0751929

Method of Determining Pyrrole-Imidazole Polyamide in Rat Plasma Using Ultra-Fast Liquid Chromatography-Ultraviolet Spectrometry

超高速液体クロマトグラフィー-紫外分光法を用いたラット血漿中のピロール-イミダゾールポリアミドの定量法

Author (7)： Miyamoto Aoi (Laboratory of Clinical Pharmacokinetics, School of Pharmacy, Nihon University) ,  Yagishita Kouta (Laboratory of Clinical Pharmacokinetics, School of Pharmacy, Nihon University) ,  Aoyama Takahiko (Laboratory of Clinical Pharmacokinetics, School of Pharmacy, Nihon University) ,  Abe Masanori (Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine) ,  Fukuda Noboru (Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine) ,  Fukuda Noboru (Research Center Nihon University) ,  Matsumoto Yoshiaki (Laboratory of Clinical Pharmacokinetics, School of Pharmacy, Nihon University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 43  Issue： 1  Page： 124-128(J-STAGE)  Publication year： 2020 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： *pyrrole imidazole polyamide ,...

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Author keywords (6)： pyrrole-imidazole polyamide ,  ultra-fast LC ,  drug-discovery research ,  pyrrole-imidazole polyamide ,  ultra-fast LC ,  drug-discovery research

JST classification (1)： Analysis of drugs  (GV01040Q)

Substance index (1)： Phenacetin

Reference (14)：

• 1) Dervan PB. Molecular recognition of DNA by small molecules. Bioorg. Med. Chem., 9, 2215-2235 (2001).
• 2) Trauger JW, Baird EE, Dervan PB. Recognition of DNA by designed ligands at subnanomolar concentrations. Nature, 382, 559-561 (1996).
• 3) White S, Baird EE, Dervan PB. On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides. Chem. Biol., 4, 569-578 (1997).
• 4) Murty MS, Sugiyama H. Biology of N-methylpyrrole-Nmethylimidazole hairpin polyamide. Biol. Pharm. Bull., 27, 468-474 (2004).
• 5) Dickinson LA, Gulizia RJ, Trauger JW, Baird EE, Mosier DE, Gottesfeld JM, Dervan PB. Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands. Proc. Natl. Acad. Sci. U.S.A., 95, 12890-12895 (1998).

Terms in the title (6)： 高速液体クロマトグラフィー ,  紫外分光法 ,  ラット ,  血漿 ,  ピロール-イミダゾールポリアミド ,  定量法