Art

J-GLOBAL ID：202002249025134813   Reference number：20A0227718

Monoclonal anti-dsDNA antibody 2C10 escorts DNA to intracellular DNA sensors in normal mononuclear cells and stimulates secretion of multiple cytokines implicated in lupus pathogenesis

モノクローナル抗dsDNA抗体2C10は正常単核細胞における細胞内DNAセンサにDNAセンサを導入し,ループス病因に関与する複数のサイトカインの分泌を刺激する【JST・京大機械翻訳】

Author (3)： Inoue K. (Department of Microbiology and Immunology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan) ,  Ishizawa M. (Department of Immunopathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan) ,  Kubota T. (Department of Immunopathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan)
Material： Clinical and Experimental Immunology  (Clin Exp Immunol)
Volume： 199  Issue： 2  Page： 150-162  Publication year： 2020 
JST Material Number： E0159B  ISSN： 0009-9104  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： There have been many studies o...

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Thesaurus term： TNF ,  *monocyte ,  Antigen-Antibody Complex ,  human ,  *cytokine ,  pathological state ,  interleukin ,  internalization ,  *DNA ,  Toll like receptor ,  interferon ,  anti-DNA antibody ,  *pathogenesis ,  systemic lupus erythematosus ,  Melanoma

Author keywords (4)： anti-DNA antibodies ,  endocytosis ,  macropinocytosis ,  systemic lupus erythematosus

JST classification (3)： Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Immunological reaction in general  (ED03010T) ,  Gene expression  (EC02040Q)

Terms in the title (8)： 抗dsDNA抗体 ,  単核細胞 ,  DNAセンサ ,  ループス ,  病因 ,  サイトカイン ,  分泌 ,  刺激