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J-GLOBAL ID：202002249114486908   Reference number：20A2154683

Knockdown of microglial Cav2.2 N-type voltage-dependent Ca²⁺ channel ameliorates behavioral deficits in a mouse model of Parkinson’s disease

ミクログリアCav2.2N型電圧依存性Ca2+チャンネルのノックダウンはParkinson病のマウスモデルにおいて行動欠損を改善する【JST・京大機械翻訳】

Author (5)： Saegusa Hironao (Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan) ,  Li Xu (Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan) ,  Wang Xinshuang (Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan) ,  Kayakiri Midori (Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan) ,  Tanabe Tsutomu (Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan)
Material： FEBS Letters  (for the Rapid Publication of Short Reports in Biochemistry, Biophysics)
Volume： 594  Issue： 17  Page： 2914-2922  Publication year： 2020 
JST Material Number： D0575A  ISSN： 0014-5793  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Cav2.2 N-type voltage-dependen...

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Thesaurus term： neuron ,  excitation (physiology) ,  Substantia Nigra ,  channel ,  *Parkinson's disease ,  voltage dependence ,  *microglia ,  voltage dependent calcium channel ,  *Gene Knockdown Technique ,  voltage dependency ,  Cav1.2 ,  mouse model ,  Mesencephalon ,  telencephalon ,  Prosencephalon ,  basal ganglia

Author keywords (6)： Cav2.2 ,  microglia ,  MPTP ,  N-type voltage-dependent Ca2+ channel ,  Parkinson’s disease ,  VDCC

JST classification (1)： Transport of cell membrane  (EF04020R)

Terms in the title (8)： ミクログリア ,  電圧依存性 ,  Ca2+チャンネル ,  ノックダウン ,  Parkinson病 ,  マウスモデル ,  行動 ,  欠損