Art

J-GLOBAL ID：202002249152609972   Reference number：20A2791841

Mechanistic study of preparation of drug/polymer/surfactant ternary hot extrudates to obtain small and stable drug nanocrystal suspensions

低分子および安定な薬物ナノ結晶懸濁液を得るための薬物/高分子/界面活性剤三成分熱間押出物の調製の機構研究【JST・京大機械翻訳】

Author (7)： Omagari Katsuhiko (Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan) ,  Ueda Keisuke (Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan) ,  Zhijing Zhao (Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan) ,  Higashi Kenjirou (Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan) ,  Inoue Motoki (Department of Molecular Pharmaceutics, Meiji Pharmaceutical University, Kiyose, 2-522-1 Noshino, Kiyose-shi, Tokyo 204-8588, Japan) ,  Fukami Toshiro (Department of Molecular Pharmaceutics, Meiji Pharmaceutical University, Kiyose, 2-522-1 Noshino, Kiyose-shi, Tokyo 204-8588, Japan) ,  Moribe Kunikazu (Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan)
Material： International Journal of Pharmaceutics  (Int J Pharm)
Volume： 591  Page： Null  Publication year： 2020 
JST Material Number： A0285B  ISSN： 0378-5173  CODEN： IJPHD  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： We studied optimized condition...

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Thesaurus term： crystal growth ,  *suspension(disperse system) ,  low temperature ,  dissolution ,  *surfactant ,  *macromolecule ,  crystallinity ,  *extruded product ,  *hot extrusion ,  *small molecule ,  amorphization ,  nano particle ,  *nano crystal ,  shear force
Semi thesaurus term： 固体NMR , 【Automatic Indexing@JST】

Author keywords (6)： Drug nanocrystal ,  Hot extrusion ,  Crystal growth ,  Solid-state NMR ,  FT-Raman ,  Crystallinity

JST classification (1)： Physicochemical characteristics of drugs  (GV01060M)

Terms in the title (9)： 低分子 ,  薬物 ,  ナノ結晶 ,  懸濁液 ,  高分子 ,  界面活性剤 ,  熱間押出 ,  調製 ,  研究