Art

J-GLOBAL ID：202002249474259947   Reference number：20A0573091

Structure-Specific Cleavage of an RNA Repeat Expansion with a Dimeric Small Molecule Is Advantageous over Sequence-Specific Recognition by an Oligonucleotide

二量体小分子によるRNA反復拡大の構造特異的開裂はオリゴヌクレオチドによる配列特異的認識に有利である【JST・京大機械翻訳】

Author (6)： Benhamou Raphael I. (Department of Chemistry, The Scripps Research Institute, Florida, United States) ,  Angelbello Alicia J. (Department of Chemistry, The Scripps Research Institute, Florida, United States) ,  Andrews Ryan J. (Roy J. Carver Department of Biophysics, Biochemistry, and Molecular Biology, Iowa State University, Iowa, United States) ,  Wang Eric T. (Department of Molecular Genetics and Microbiology, Center for NeuroGenetics, UF Genetics Institute, University of Florida, Florida, United States) ,  Moss Walter N. (Roy J. Carver Department of Biophysics, Biochemistry, and Molecular Biology, Iowa State University, Iowa, United States) ,  Disney Matthew D. (Department of Chemistry, The Scripps Research Institute, Florida, United States)
Material： ACS Chemical Biology
Volume： 15  Issue： 2  Page： 485-493  Publication year： 2020 
JST Material Number： W5037A  ISSN： 1554-8937  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Myotonic dystrophy type 2 (DM2...

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Thesaurus term： *dimer ,  heredity ,  conjugation ,  mRNA ,  intron ,  bleomycin ,  *oligonucleotide ,  chimera ,  natural material ,  nucleic acid ,  *small molecule ,  pathological state ,  *RNA ,  molecular recognition ,  muscular dystrophy

JST classification (2)： Gene expression  (EC02040Q) ,  Basic neurology  (GN01020W)

Terms in the title (7)： 二量体 ,  小分子 ,  RNA ,  反復 ,  拡大 ,  開裂 ,  オリゴヌクレオチド