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J-GLOBAL ID：202002249633890640   Reference number：20A0652956

NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation

NrBP1含有Crl2/Crl4aは分解のためのBRI2とBRI3を標的とすることによりアミロイドβ産生を調節する【JST・京大機械翻訳】

Author (17)： Yasukawa Takashi (Department of Functional Genomics, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan) ,  Tsutsui Aya (Department of Functional Genomics, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan) ,  Tomomori-Sato Chieri (Stowers Institute for Medical Research, Kansas City, MO 64110, USA) ,  Sato Shigeo (Stowers Institute for Medical Research, Kansas City, MO 64110, USA) ,  Saraf Anita (Stowers Institute for Medical Research, Kansas City, MO 64110, USA) ,  Washburn Michael P. (Stowers Institute for Medical Research, Kansas City, MO 64110, USA) ,  Washburn Michael P. (Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA) ,  Florens Laurence (Stowers Institute for Medical Research, Kansas City, MO 64110, USA) ,  Terada Tohru (Interfaculty Initiative in Information Studies, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan) ,  Terada Tohru (Agricultural Bioinformatics Research Unit, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan) ,  Shimizu Kentaro (Agricultural Bioinformatics Research Unit, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan) ,  Shimizu Kentaro (Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan) ,  Conaway Ronald C. (Stowers Institute for Medical Research, Kansas City, MO 64110, USA) ,  Conaway Ronald C. (Department of Biochemistry and Molecular Biology, Kansas University Medical Center, Kansas City, KS 66160, USA) ,  Conaway Joan W. (Stowers Institute for Medical Research, Kansas City, MO 64110, USA) ,  Conaway Joan W. (Department of Biochemistry and Molecular Biology, Kansas University Medical Center, Kansas City, KS 66160, USA) ,  Aso Teijiro (Department of Functional Genomics, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan)
Material： Cell Reports
Volume： 30  Issue： 10  Page： 3478-3491.e6  Publication year： 2020 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Alzheimer’s disease (AD) is a ...

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Thesaurus term： interaction ,  oligomerization ,  precursor(substance) ,  *amyloid ,  therapeutic planning ,  Alzheimer disease ,  substrate(biochemistry) ,  receptor ,  ubiquitination ,  neuron ,  dimerization ,  protein ,  chaperone protein ,  *amyloid beta-protein ,  fibrous disease

Author keywords (10)： E3 ubiquitin ligase ,  CRL ,  Cullin ,  ubiquitination ,  NRBP1 ,  Alzheimer’s disease ,  amyloid β ,  amyloid-β precursor protein/APP ,  BRI2/ITM2B ,  BRI3/ITM2C

JST classification (3)： Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S) ,  Enzyme in general  (EB09010D)

Terms in the title (4)： 分解 ,  標的 ,  アミロイドβ ,  調節