Art

J-GLOBAL ID：202002250367121713   Reference number：20A0061709

Dopamine attenuates lipopolysaccharide-induced expression of proinflammatory cytokines by inhibiting the nuclear translocation of NF-κB p65 through the formation of dopamine quinone in microglia.

ドーパミンはミクログリアにおけるドーパミンキノンの形成を介してNF-κB p65の核内移行を阻害することによりリポ多糖類誘導炎症性サイトカインの発現を減弱する【JST・京大機械翻訳】

Author (6)： Yoshioka Yasuhiro (Laboratory of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan) ,  Sugino Yuta (Laboratory of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan) ,  Shibagaki Fumiya (Laboratory of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan) ,  Yamamuro Akiko (Laboratory of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan) ,  Ishimaru Yuki (Laboratory of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan) ,  Maeda Sadaaki (Laboratory of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan)
Material： European Journal of Pharmacology  (Eur J Pharmacol)
Volume： 866  Page： Null  Publication year： 2020 
JST Material Number： B0841A  ISSN： 0014-2999  CODEN： EJPHAZ  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Many reports have indicated th...

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Thesaurus term： pretreatment ,  *microglia ,  oxidation ,  interleukin 6 ,  receptor ,  interleukin 1 ,  primary culture ,  *cytokine ,  central nervous system ,  *NF-kappaB ,  *lipopolysaccharide ,  TNF ,  *quinone ,  Western blotting ,  *inflammatory cytokine

Author keywords (5)： Microglia ,  Proinflammatory cytokines ,  Dopamine ,  Dopamine quinone ,  Nuclear factor-kappa B

JST classification (2)： Basic research of anti-inflammatory drugs  (GW15010T) ,  Basic research of psychotropic drugs  (GW03100Y)

Terms in the title (11)： ドーパミン ,  ミクログリア ,  NF-κB ,  p65 ,  核内移行 ,  阻害 ,  リポ多糖類 ,  誘導 ,  炎症性サイトカイン ,  発現 ,  減弱